2026-08-13T07:18:18Zhttps://repisalud.isciii.es/rest/oai/request
oai:repisalud.isciii.es:20.500.12105/233272024-11-28T20:15:21Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967
Repisalud author Haddadin, Zaid author Batarseh, Einas author Hamdan, Lubna author Stewart, Laura S author Piya, Bhinnata author Rahman, Herdi author Spieker, Andrew J author Chappell, James author Wikswo, Mary E author Dunn, John R author Payne, Daniel C author Vinje, Jan author Hall, Aron J author Halasa, Natasha 2024-09-18T06:44:16Z 2024-09-18T06:44:16Z 2021-10-01 Haddadin Z, Batarseh E, Hamdan L, Stewart LS, Piya B, Rahman H, et al. Characteristics of GII.4 Norovirus Versus Other Genotypes in Sporadic Pediatric Infections in Davidson County, Tennessee, USA. Clin Infect Dis. 2021 Oct 1;73(7):E1525-31. 10.1093/cid/ciaa1001 1537-6591 1058-4838 Clinical Infectious Diseases https://hdl.handle.net/20.500.13003/19485 32667045 L632363091 2-s2.0-85118283429 https://hdl.handle.net/20.500.12105/23327 729829500019 Background. Norovirus is a leading cause of epidemic acute gastroenteritis (AGE), with most outbreaks occurring during winter. The majority of outbreaks are caused by GII.4 noroviruses; however, data to support whether this is true for sporadic medically attended AGE are limited. Therefore, we sought to compare the clinical characteristics and seasonality of GII.4 vs non-GII.4 viruses. Methods. Children aged 15 days -17 years with AGE symptoms were recruited from the outpatient, emergency department, and inpatient settings at Vanderbilt Children's Hospital, Davidson County, Nashville, Tennessee, from December 2012 -November 2015. Stool specimens were tested using qRT-PCR for GI and GII noroviruses and subsequently genotyped by sequencing a partial region of the capsid gene. Results. A total of 3705 patients were enrolled, and stool specimens were collected and tested from 2885 (78%) enrollees. Overall, 636 (22%) samples were norovirus-positive, of which 567 (89%) were GII. of the 460 (81%) genotyped GII-positive samples, 233 (51%) were typed as GII.4 and 227 (49%) as non-GII.4. Compared with children with non-GII.4 infections, children with GII.4 infections were younger, more likely to have diarrhea, and more likely to receive oral rehydration fluids. Norovirus was detected year-round and peaked during winter. Conclusions. Approximately 40% of sporadic pediatric norovirus AGE cases were caused by GII.4 norovirus. Children infected with GII.4 had more severe symptoms that required more medical care. Seasonal variations were noticed among different genotypes. These data highlight the importance of continuous norovirus surveillance and provide important information on which strains pediatric norovirus vaccines should protect against. eng Norovirus Surveillance Sporadic Genotypes Acute gastroenteritis Characteristics of GII.4 Norovirus Versus Other Genotypes in Sporadic Pediatric Infections in Davidson County, Tennessee, USA research article