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oai:repisalud.isciii.es:20.500.12105/233222024-11-29T06:01:09Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967
Repisalud author Morell Garcia, Daniel author Ramos-Chavarino, David author Bauça, Josep Miquel author Argente del Castillo, Paula author Ballesteros-Vizoso, Maria Antonieta author García de Guadiana-Romualdo, Luis author Gomez-Cobo, Cristina author Albert Pou, J author Amezaga-Menendez, Rocio author Alonso-Fernandez, Alberto author Llompart, Isabel author Garcia-Raja, Ana 2024-09-18T06:44:11Z 2024-09-18T06:44:11Z 2021-05-27 Morell-Garcia D, Ramos-Chavarino D, Bauca JM, del Castillo PA, Ballesteros-Vizoso MA, de Guadiana-Romualdo LG, et al. Urine biomarkers for the prediction of mortality in COVID-19 hospitalized patients. Sci Rep. 2021 May 27;11(1):11134. 2045-2322 https://hdl.handle.net/20.500.13003/19888 https://hdl.handle.net/20.500.12105/23322 34045530 10.1038/s41598-021-90610-y Scientific Reports 2-s2.0-85107015247 658389400049 L635191894 Risk factors associated with severity and mortality attributable to COVID-19 have been reported in different cohorts, highlighting the occurrence of acute kidney injury (AKI) in 25% of them. Among other, SARS-CoV-2 targets renal tubular cells and can cause acute renal damage. The aim of the present study was to evaluate the usefulness of urinary parameters in predicting intensive care unit (ICU) admission, mortality and development of AKI in hospitalized patients with COVID-19. Retrospective observational study, in a tertiary care hospital, between March 1st and April 19th, 2020. We recruited adult patients admitted consecutively and positive for SARS-CoV-2. Urinary and serum biomarkers were correlated with clinical outcomes (AKI, ICU admission, hospital discharge and in-hospital mortality) and evaluated using a logistic regression model and ROC curves. A total of 199 COVID-19 hospitalized patients were included. In AKI, the logistic regression model with a highest area under the curve (AUC) was reached by the combination of urine blood and previous chronic kidney disease, with an AUC of 0.676 (95%CI 0.512-0.840; p=0.023); urine specific weight, sodium and albumin in serum, with an AUC of 0.837 (95% CI 0.766-0.909; p<0.001) for ICU admission; and age, urine blood and lactate dehydrogenase levels in serum, with an AUC of 0.923 (95%CI 0.866-0.979; p<0.001) for mortality prediction. For hospitalized patients with COVID-19, renal involvement and early alterations of urinary and serum parameters are useful as prognostic factors of AKI, the need for ICU admission and death. eng Urine biomarkers for the prediction of mortality in COVID-19 hospitalized patients research article