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oai:repisalud.isciii.es:20.500.12105/233212024-11-28T18:50:11Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16963col_20.500.12105_16967

00925njm 22002777a 4500 dc Zamarron, Ester author Jaureguizar, Ana author Garcia-Sanchez, Aldara author Diaz-Cambriles, Trinidad author Alonso-Fernandez, Alberto author Lores, Vanesa author Mediano San Andres, Olga author Rodriguez-Rodriguez, Paula author Cabello Pelegrin, Sheila author Morales-Ruiz, Enrique author Ramirez-Prieto, Maria T author Valiente-Diae, Maria Isabel author Gomez-Garcia, Teresa author Garcia-Rio, Francisco author Spanish Sleep Network author 2021-03-11 Obstructive sleep apnea (OSA) is a recognized risk factor for the development of diabetic kidney disease (DKD). Our objectives were to compare the urinary albumin-creatinine ratio (UACR) and estimated glomerular filtration rate (eGFR) of patients with DKD according to OSA severity, and to evaluate the contribution of sleep parameters to their renal function. In a multicenter, observational, cross-sectional study, 214 patients with DKD were recruited. After a sleep study, UACR and eGFR were measured, as well as serum creatinine, fasting glucose, glycated hemoglobin, insulin resistance, lipid profile and C-reactive protein. UACR was higher in severe OSA patients (920 +/- 1053 mg/g) than in moderate (195 +/- 232 mg/g, p <0.001) or mild OSA/non-OSA subjects (119 +/- 186 mg/g, p <0.001). At the same time, eGFR showed an OSA severity-dependent reduction (48 +/- 23 vs. 59 +/- 21 vs. 73 +/- 19 ml/min per 1.73 m(2), respectively; p < 0.001). Apnea-hypopnea index (AHI and desaturation index (ODI) were identified as independent predictors for UACR and eGFR, respectively. Therefore, in patients with DKD under optimized treatment, severe OSA is associated with a higher UACR and a lower eGFR, reflecting an additional contribution to the impairment of their renal function, although no causality can be inferred. Zamarron E, Jaureguizar A, Garcia-Sanchez A, Diaz-Cambriles T, Alonso-Fernandez A, Lores V, et al. Obstructive sleep apnea is associated with impaired renal function in patients with diabetic kidney disease. Sci Rep. 2021 Mar 11;11(1):5675. 10.1038/s41598-021-85023-w 2045-2322 Scientific Reports https://hdl.handle.net/20.500.13003/19722 33707611 L634555145 2-s2.0-85102424422 https://hdl.handle.net/20.500.12105/23321 629620800003 Obstructive sleep apnea is associated with impaired renal function in patients with diabetic kidney disease