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00925njm 22002777a 4500 dc Domínguez-López, Inés author Parilli-Moser, Isabella author Arancibia-Riveros, Camila author Tresserra-Rimbau, Anna author Martinez-Gonzalez, Miguel Angel author Ortega-Azorin, Carolina author Salas-Salvado, Jordi author Castaner, Olga author Lapetra, Jose author Aros, Fernando author Fiol Sala, Miquel author Serra-Majem, Lluis author Pinto, Xavier author Gomez-Gracia, Enrique author Ros, Emilio author Lamuela-Raventos, Rosa M author Estruch, Ramon author 2021-08 Postmenopausal women are at higher risk of developing cardiovascular diseases due to changes in lipid profile and body fat, among others. The aim of this study was to evaluate the association of urinary tartaric acid, a biomarker of wine consumption, with anthropometric (weight, waist circumference, body mass index (BMI), and waist-to-height ratio), blood pressure, and biochemical variables (blood glucose and lipid profile) that may be affected during the menopausal transition. This sub-study of the PREDIMED (Prevencion con Dieta Mediterranea) trial included a sample of 230 women aged 60-80 years with high cardiovascular risk at baseline. Urine samples were diluted and filtered, and tartaric acid was analyzed by liquid chromatography coupled to electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS). Correlations between tartaric acid and the study variables were adjusted for age, education level, smoking status, physical activity, BMI, cholesterol-lowering, antihypertensive, and insulin treatment, total energy intake, and consumption of fruits, vegetables, and raisins. A strong association was observed between wine consumption and urinary tartaric acid (0.01 mu g/mg (95% confidence interval (CI): 0.01, 0.01), p-value < 0.001). Total and low-density lipoprotein (LDL) cholesterol were inversely correlated with urinary tartaric acid (-3.13 mu g/mg (-5.54, -0.71), p-value = 0.016 and -3.03 mu g/mg (-5.62, -0.42), p-value = 0.027, respectively), whereas other biochemical and anthropometric variables were unrelated. The results suggest that wine consumption may have a positive effect on cardiovascular health in postmenopausal women, underpinning its nutraceutical properties. Dominguez-Lopez I, Parilli-Moser I, Arancibia-Riveros C, Tresserra-Rimbau A, Martinez-Gonzalez MA, Ortega-Azorin C, et al. Urinary Tartaric Acid, a Biomarker of Wine Intake, Correlates with Lower Total and LDL Cholesterol. Nutrients. 2021 Aug;13(8):2883. https://hdl.handle.net/20.500.13003/19887 https://hdl.handle.net/20.500.12105/23314 34445043 10.3390/nu13082883 2072-6643 Nutrients 2-s2.0-85113137299 690052000001 L2013483947 PREDIMED Mediterranean diet Lipid profile Cardiovascular risk Polyphenols Menopause Body fat Biomarkers Tartaric acid Urinary Tartaric Acid, a Biomarker of Wine Intake, Correlates with Lower Total and LDL Cholesterol