2026-05-21T23:06:57Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/233132024-11-28T19:31:43Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967
Repisalud
author
Sanchis, Pilar
author
Lopez-Gonzalez, Angel-Arturo
author
Costa-Bauza, Antonia
author
Busquets-Cortés, Carla
author
Riutord, Pere
author
Calvó García, Paula
author
Grases, Felix
2024-09-18T06:44:05Z
2024-09-18T06:44:05Z
2021-08
Sanchis P, Lopez-Gonzalez AA, Costa-Bauza A, Busquets-Cortes C, Riutord P, Calvo P, et al. Understanding the Protective Effect of Phytate in Bone Decalcification Related-Diseases. Nutrients. 2021 Aug;13(8):2859.
10.3390/nu13082859
2072-6643
Nutrients
https://hdl.handle.net/20.500.13003/19886
34445019
L2013483971
2-s2.0-85113237366
https://hdl.handle.net/20.500.12105/23313
689812100001
Myo-inositol hexaphosphate (phytate; IP6) is a natural compound that is abundant in cereals, legumes, and nuts, and it can bind to crystal surfaces and disturb crystal development, acting as crystallization inhibitor. The adsorption of such inhibitors to crystal faces can also inhibit crystal dissolution. The binding of phytate to metal cofactors suggests that it could be used for treatment of osteoporosis. Our in-vitro study showed that phytate inhibits dissolution of hydroxyapatite (HAP). The effect of phytate was similar to that of alendronate and greater than that of etidronate. This led us to perform a cross-sectional study to investigate the impact of consumption of IP6 on bone mineral density (BMD) in post-menopausal women. Our data indicate that BMD and t-score of lumbar spine increased with increasing phytate consumption, and a phytate consumption higher than 307 mg/day was associated with a normal BMD (t-score > -1). These data suggest that phytate may have a protective effect in bone decalcification by adsorbing on the surfaces of HAP, and a daily consumption of phytate-rich foods (at least one serving/day of legumes or nuts) may help to prevent or minimize bone-loss disorders, such as osteoporosis. However, further studies are needed to gain a better understanding about the mechanism of inhibition of phytate in bone-related diseases (see graphical abstract).
eng
Hydroxyapatite
Bone resorption
Phytate
Alendronate
Etidronate
Understanding the Protective Effect of Phytate in Bone Decalcification Related-Diseases
research article