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00925njm 22002777a 4500 dc Sanchis, Pilar author Lopez-Gonzalez, Angel-Arturo author Costa-Bauza, Antonia author Busquets-Cortés, Carla author Riutord, Pere author Calvó García, Paula author Grases, Felix author 2021-08 Myo-inositol hexaphosphate (phytate; IP6) is a natural compound that is abundant in cereals, legumes, and nuts, and it can bind to crystal surfaces and disturb crystal development, acting as crystallization inhibitor. The adsorption of such inhibitors to crystal faces can also inhibit crystal dissolution. The binding of phytate to metal cofactors suggests that it could be used for treatment of osteoporosis. Our in-vitro study showed that phytate inhibits dissolution of hydroxyapatite (HAP). The effect of phytate was similar to that of alendronate and greater than that of etidronate. This led us to perform a cross-sectional study to investigate the impact of consumption of IP6 on bone mineral density (BMD) in post-menopausal women. Our data indicate that BMD and t-score of lumbar spine increased with increasing phytate consumption, and a phytate consumption higher than 307 mg/day was associated with a normal BMD (t-score > -1). These data suggest that phytate may have a protective effect in bone decalcification by adsorbing on the surfaces of HAP, and a daily consumption of phytate-rich foods (at least one serving/day of legumes or nuts) may help to prevent or minimize bone-loss disorders, such as osteoporosis. However, further studies are needed to gain a better understanding about the mechanism of inhibition of phytate in bone-related diseases (see graphical abstract). Sanchis P, Lopez-Gonzalez AA, Costa-Bauza A, Busquets-Cortes C, Riutord P, Calvo P, et al. Understanding the Protective Effect of Phytate in Bone Decalcification Related-Diseases. Nutrients. 2021 Aug;13(8):2859. 10.3390/nu13082859 2072-6643 Nutrients https://hdl.handle.net/20.500.13003/19886 34445019 L2013483971 2-s2.0-85113237366 https://hdl.handle.net/20.500.12105/23313 689812100001 Hydroxyapatite Bone resorption Phytate Alendronate Etidronate Understanding the Protective Effect of Phytate in Bone Decalcification Related-Diseases