2026-04-29T02:37:35Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/233052024-11-28T19:33:28Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967
Repisalud
author
Valero, Ana
author
Rodriguez-Gascon, Alicia
author
Isla, Arantxa
author
Barrasa, Helena
author
del Barrio-Tofino, Ester
author
Oliver, Antonio
author
Canut, Andres
author
Solinis, Maria Angeles
2024-09-18T06:43:59Z
2024-09-18T06:43:59Z
2021-11
Valero A, Rodriguez-Gascon A, Isla A, Barrasa H, del Barrio-Tofino E, Oliver A, et al. Pseudomonas aeruginosa & nbsp;Susceptibility in Spain: Antimicrobial Activity and Resistance Suppression Evaluation by PK/PD Analysis. Pharmaceutics. 2021 Nov;13(11):1899.
https://hdl.handle.net/20.500.13003/19780
https://hdl.handle.net/20.500.12105/23305
34834314
10.3390/pharmaceutics13111899
1999-4923
Pharmaceutics
2-s2.0-85119620790
727834000001
L2014592906
Pseudomonas aeruginosa remains one of the major causes of healthcare-associated infection in Europe; in 2019, 12.5% of invasive isolates of P. aeruginosa in Spain presented combined resistance to & GE;3 antimicrobial groups. The Spanish nationwide survey on P. aeruginosa antimicrobial resistance mechanisms and molecular epidemiology was published in 2019. Based on the information from this survey, the objective of this work was to analyze the overall antimicrobial activity of the antipseudomonal antibiotics considering pharmacokinetic/pharmacodynamic (PK/PD) analysis. The role of PK/PD to prevent or minimize resistance emergence was also evaluated. A 10,000-subject Monte Carlo simulation was executed to calculate the probability of target attainment (PTA) and the cumulative fraction of response (CFR) considering the minimum inhibitory concentration (MIC) distribution of bacteria isolated in ICU or medical wards, and distinguishing between sample types (respiratory and non-respiratory). Ceftazidime/avibactam followed by ceftolozane/tazobactam and colistin, categorized as the Reserve by the Access, Watch, Reserve (AWaRe) classification of the World Health Organization, were the most active antimicrobials, with differences depending on the admission service, sample type, and dose regimen. Discrepancies between EUCAST-susceptibility breakpoints for P. aeruginosa and those estimated by PK/PD analysis were detected. Only standard doses of ceftazidime/avibactam and ceftolozane/tazobactam provided drug concentrations associated with resistance suppression.
eng
Pseudomonas aeruginosa
Pharmacokinetic/pharmacodynamic (PK/PD) analysis
Monte Carlo simulation
Antimicrobial resistance
Probability of target attainment (PTA)
Cumulative fraction of response (CFR)
Susceptibility in Spain: Antimicrobial Activity and Resistance Suppression Evaluation by PK/PD Analysis
research article