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oai:repisalud.isciii.es:20.500.12105/233052024-11-28T19:33:28Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967

00925njm 22002777a 4500 dc Valero, Ana author Rodriguez-Gascon, Alicia author Isla, Arantxa author Barrasa, Helena author del Barrio-Tofino, Ester author Oliver, Antonio author Canut, Andres author Solinis, Maria Angeles author 2021-11 Pseudomonas aeruginosa remains one of the major causes of healthcare-associated infection in Europe; in 2019, 12.5% of invasive isolates of P. aeruginosa in Spain presented combined resistance to & GE;3 antimicrobial groups. The Spanish nationwide survey on P. aeruginosa antimicrobial resistance mechanisms and molecular epidemiology was published in 2019. Based on the information from this survey, the objective of this work was to analyze the overall antimicrobial activity of the antipseudomonal antibiotics considering pharmacokinetic/pharmacodynamic (PK/PD) analysis. The role of PK/PD to prevent or minimize resistance emergence was also evaluated. A 10,000-subject Monte Carlo simulation was executed to calculate the probability of target attainment (PTA) and the cumulative fraction of response (CFR) considering the minimum inhibitory concentration (MIC) distribution of bacteria isolated in ICU or medical wards, and distinguishing between sample types (respiratory and non-respiratory). Ceftazidime/avibactam followed by ceftolozane/tazobactam and colistin, categorized as the Reserve by the Access, Watch, Reserve (AWaRe) classification of the World Health Organization, were the most active antimicrobials, with differences depending on the admission service, sample type, and dose regimen. Discrepancies between EUCAST-susceptibility breakpoints for P. aeruginosa and those estimated by PK/PD analysis were detected. Only standard doses of ceftazidime/avibactam and ceftolozane/tazobactam provided drug concentrations associated with resistance suppression. Valero A, Rodriguez-Gascon A, Isla A, Barrasa H, del Barrio-Tofino E, Oliver A, et al. Pseudomonas aeruginosa & nbsp;Susceptibility in Spain: Antimicrobial Activity and Resistance Suppression Evaluation by PK/PD Analysis. Pharmaceutics. 2021 Nov;13(11):1899. https://hdl.handle.net/20.500.13003/19780 https://hdl.handle.net/20.500.12105/23305 34834314 10.3390/pharmaceutics13111899 1999-4923 Pharmaceutics 2-s2.0-85119620790 727834000001 L2014592906 Pseudomonas aeruginosa Pharmacokinetic/pharmacodynamic (PK/PD) analysis Monte Carlo simulation Antimicrobial resistance Probability of target attainment (PTA) Cumulative fraction of response (CFR) Susceptibility in Spain: Antimicrobial Activity and Resistance Suppression Evaluation by PK/PD Analysis