2026-07-24T06:25:19Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/232972024-11-28T19:58:25Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967
Repisalud
author
Antich-Rosselló, Miquel
author
Forteza-Genestra, Maria Antonia
author
Monjo, Marta
author
Ramis, Joana Maria
2024-09-18T06:43:54Z
2024-09-18T06:43:54Z
2021-08
Antich-Rossello M, Forteza-Genestra MA, Monjo M, Ramis JM. Platelet-Derived Extracellular Vesicles for Regenerative Medicine. Int J Mol Sci. 2021 Aug;22(16):8580.
10.3390/ijms22168580
1422-0067
International Journal of Molecular Sciences
https://hdl.handle.net/20.500.13003/19750
34445286
L2013331979
2-s2.0-85112114391
https://hdl.handle.net/20.500.12105/23297
689124000001
Extracellular vesicles (EVs) present a great potential for the development of new treatments in the biomedical field. To be used as therapeutics, many different sources have been used for EVs obtention, while only a few studies have addressed the use of platelet-derived EVs (pEVs). In fact, pEVs have been shown to intervene in different healing responses, thus some studies have evaluated their regenerative capability in wound healing or hemorrhagic shock. Even more, pEVs have proven to induce cellular differentiation, enhancing musculoskeletal or neural regeneration. However, the obtention and characterization of pEVs is widely heterogeneous and differs from the recommendations of the International Society for Extracellular Vesicles. Therefore, in this review, we aim to present the main advances in the therapeutical use of pEVs in the regenerative medicine field while highlighting the isolation and characterization steps followed. The main goal of this review is to portray the studies performed in order to enhance the translation of the pEVs research into feasible therapeutical applications.
eng
Extracellular vesicles
Exosomes
Platelets
Regenerative medicine
Platelet-Derived Extracellular Vesicles for Regenerative Medicine
review article