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00925njm 22002777a 4500 dc Antich-Rosselló, Miquel author Forteza-Genestra, Maria Antonia author Monjo, Marta author Ramis, Joana Maria author 2021-08 Extracellular vesicles (EVs) present a great potential for the development of new treatments in the biomedical field. To be used as therapeutics, many different sources have been used for EVs obtention, while only a few studies have addressed the use of platelet-derived EVs (pEVs). In fact, pEVs have been shown to intervene in different healing responses, thus some studies have evaluated their regenerative capability in wound healing or hemorrhagic shock. Even more, pEVs have proven to induce cellular differentiation, enhancing musculoskeletal or neural regeneration. However, the obtention and characterization of pEVs is widely heterogeneous and differs from the recommendations of the International Society for Extracellular Vesicles. Therefore, in this review, we aim to present the main advances in the therapeutical use of pEVs in the regenerative medicine field while highlighting the isolation and characterization steps followed. The main goal of this review is to portray the studies performed in order to enhance the translation of the pEVs research into feasible therapeutical applications. Antich-Rossello M, Forteza-Genestra MA, Monjo M, Ramis JM. Platelet-Derived Extracellular Vesicles for Regenerative Medicine. Int J Mol Sci. 2021 Aug;22(16):8580. 10.3390/ijms22168580 1422-0067 International Journal of Molecular Sciences https://hdl.handle.net/20.500.13003/19750 34445286 L2013331979 2-s2.0-85112114391 https://hdl.handle.net/20.500.12105/23297 689124000001 Extracellular vesicles Exosomes Platelets Regenerative medicine Platelet-Derived Extracellular Vesicles for Regenerative Medicine