2026-05-21T23:08:42Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/232932024-11-28T19:32:16Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967
Repisalud
author
Torrens-Mas, Margalida
author
Perelló-Campaner, Catalina
author
Navas-Enamorado, Cayetano
author
Ibarguen-Gonzalez, Lesly
author
Sanchez-Polo, Andrés
author
Segura-Sampedro, Juan José
author
Masmiquel Comas, Lluis
author
Barceló, Carles
author
Gonzalez-Freire, Marta
2024-09-18T06:43:52Z
2024-09-18T06:43:52Z
2021-10
Torrens-Mas M, Perello-Reus C, Navas-Enamorado C, Ibarguen-Gonzalez L, Sanchez-Polo A, Segura-Sampedro JJ, et al. Organoids: An Emerging Tool to Study Aging Signature across Human Tissues. Modeling Aging with Patient-Derived Organoids. Int J Mol Sci. 2021 Oct;22(19):10547.
10.3390/ijms221910547
1422-0067
International Journal of Molecular Sciences
https://hdl.handle.net/20.500.13003/19732
34638891
L2013955821
2-s2.0-85116074089
https://hdl.handle.net/20.500.12105/23293
775542200009
The biology of aging is focused on the identification of novel pathways that regulate the underlying processes of aging to develop interventions aimed at delaying the onset and progression of chronic diseases to extend lifespan. However, the research on the aging field has been conducted mainly in animal models, yeast, Caenorhabditis elegans, and cell cultures. Thus, it is unclear to what extent this knowledge is transferable to humans since they might not reflect the complexity of aging in people. An organoid culture is an in vitro 3D cell-culture technology that reproduces the physiological and cellular composition of the tissues and/or organs. This technology is being used in the cancer field to predict the response of a patient-derived tumor to a certain drug or treatment serving as patient stratification and drug-guidance approaches. Modeling aging with patient-derived organoids has a tremendous potential as a preclinical model tool to discover new biomarkers of aging, to predict adverse outcomes during aging, and to design personalized approaches for the prevention and treatment of aging-related diseases and geriatric syndromes. This could represent a novel approach to study chronological and/or biological aging, paving the way to personalized interventions targeting the biology of aging.
eng
Organoids
Aging
Precision medicine
Organoids: An Emerging Tool to Study Aging Signature across Human Tissues. Modeling Aging with Patient-Derived Organoids
review article