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oai:repisalud.isciii.es:20.500.12105/232932024-11-28T19:32:16Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967

00925njm 22002777a 4500 dc Torrens-Mas, Margalida author Perelló-Campaner, Catalina author Navas-Enamorado, Cayetano author Ibarguen-Gonzalez, Lesly author Sanchez-Polo, Andrés author Segura-Sampedro, Juan José author Masmiquel Comas, Lluis author Barceló, Carles author Gonzalez-Freire, Marta author 2021-10 The biology of aging is focused on the identification of novel pathways that regulate the underlying processes of aging to develop interventions aimed at delaying the onset and progression of chronic diseases to extend lifespan. However, the research on the aging field has been conducted mainly in animal models, yeast, Caenorhabditis elegans, and cell cultures. Thus, it is unclear to what extent this knowledge is transferable to humans since they might not reflect the complexity of aging in people. An organoid culture is an in vitro 3D cell-culture technology that reproduces the physiological and cellular composition of the tissues and/or organs. This technology is being used in the cancer field to predict the response of a patient-derived tumor to a certain drug or treatment serving as patient stratification and drug-guidance approaches. Modeling aging with patient-derived organoids has a tremendous potential as a preclinical model tool to discover new biomarkers of aging, to predict adverse outcomes during aging, and to design personalized approaches for the prevention and treatment of aging-related diseases and geriatric syndromes. This could represent a novel approach to study chronological and/or biological aging, paving the way to personalized interventions targeting the biology of aging. Torrens-Mas M, Perello-Reus C, Navas-Enamorado C, Ibarguen-Gonzalez L, Sanchez-Polo A, Segura-Sampedro JJ, et al. Organoids: An Emerging Tool to Study Aging Signature across Human Tissues. Modeling Aging with Patient-Derived Organoids. Int J Mol Sci. 2021 Oct;22(19):10547. 10.3390/ijms221910547 1422-0067 International Journal of Molecular Sciences https://hdl.handle.net/20.500.13003/19732 34638891 L2013955821 2-s2.0-85116074089 https://hdl.handle.net/20.500.12105/23293 775542200009 Organoids Aging Precision medicine Organoids: An Emerging Tool to Study Aging Signature across Human Tissues. Modeling Aging with Patient-Derived Organoids