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oai:repisalud.isciii.es:20.500.12105/232872024-11-28T22:42:16Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967col_20.500.12105_16968

00925njm 22002777a 4500 dc Abbate, Manuela author Mascaro, Catalina M author Montemayor, Sofia author Casares, Miguel author Gómez Bellvert, Cristina author Ugarriza, Lucia author Tejada Gavela, Silvia author Abete, Itziar author Zulet, Maria Angeles author Sureda Gomila, Antoni author Martinez, J. Alfredo author Tur, Josep A author 2021-04 Background: Non-alcoholic fatty liver disease (NAFLD) is a risk factor for the development of chronic kidney disease (CKD), which is early marked by kidney glomerular hyperfiltration. However, the association of NAFLD with kidney glomerular hyperfiltration has not been tested so far in adults with metabolic syndrome (MetS). Aims: To assess the relationship between NAFLD and kidney glomerular hyperfiltration in adults with MetS. Methods: The study included 154 participants aged 40-60 years with MetS and NAFLD diagnosed by ultrasound. NAFLD was confirmed by MRI in 109 subjects. Participants underwent anthropometric measurements, and biochemistry testing. Estimated GFR (eGFR) was calculated using the CKD-Epidemiology Collaboration (CKD-EPI) formula; hyperfiltration was defined as eGFR >= 120 mL/min. Results: Participants with MRI-proven NAFLD showed a worse metabolic profile and higher levels of eGFR than those with no NAFLD. Presence of NAFLD and increased weight were independently associated with an increased probability of presenting hyperfiltration. Conclusions: The present study shows an association between kidney glomerular hyperfiltration and NAFLD in adults with MetS. Establishing an association between NAFLD and kidney glomerular hyperfiltration would help to earlier identify those patients at increased risk of CKD, who would benefit from an early intervention. Abbate M, Mascaro CM, Montemayor S, Casares M, Gomez C, Ugarriza L, et al. Non-Alcoholic Fatty Liver Disease Is Associated with Kidney Glomerular Hyperfiltration in Adults with Metabolic Syndrome. J Clin Med. 2021 Apr;10(8):1717. 10.3390/jcm10081717 2077-0383 Journal of Clinical Medicine https://hdl.handle.net/20.500.13003/19716 33923418 L2006980097 2-s2.0-85108423231 https://hdl.handle.net/20.500.12105/23287 644450200001 eGFR Glomerular hyperfiltration Kidney non-alcoholic fatty liver disease NAFLD Metabolic syndrome Non-Alcoholic Fatty Liver Disease Is Associated with Kidney Glomerular Hyperfiltration in Adults with Metabolic Syndrome