2026-08-29T14:15:06Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/232852024-11-28T22:56:17Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967
Repisalud
author
Ramis, Margarita R
author
Sarubbo, Fiorella
author
Moranta, David
author
Tejada Gavela, Silvia
author
Llado, Jeronia
author
Miralles, Antonio
author
Esteban, Susana
2024-09-18T06:43:48Z
2024-09-18T06:43:48Z
2021-04
Ramis MR, Sarubbo F, Moranta D, Tejada S, Llado J, Miralles A, et al. Neurochemical and Cognitive Beneficial Effects of Moderate Physical Activity and Catechin in Aged Rats. Antioxidants. 2021 Apr;10(4):621.
10.3390/antiox10040621
2076-3921
Antioxidants
https://hdl.handle.net/20.500.13003/19710
33921628
2-s2.0-85104379910
https://hdl.handle.net/20.500.12105/23285
642734100001
A healthy aging process is a requirement for good life quality. A relationship between physical activity, the consumption of antioxidants and brain health has been stablished via the activation of pathways that reduce the harmful effects of oxidative stress, by inducing enzymes such as SIRT1, which is a protector of brain function. We analyzed the cognitive and neurochemical effects of applying physical exercise in elderly rats, alone or in combination with the antioxidant catechin. Several tests of spatial and episodic memory and motor coordination were evaluated. In addition, brain monoaminergic neurotransmitters and SIRT1 protein levels were assessed in the brains of the same rats. The results show that physical activity by itself improved age-related memory and learning deficits, correlating with the restoration of brain monoaminergic neurotransmitters and SIRT1 protein levels in the hippocampus. The administration of the antioxidant catechin along with the exercise program enhanced further the monoaminergic pathways, but not the other parameters studied. These results agree with previous reports revealing a neuroprotective effect of physical activity, probably based on its ability to improve the redox status of the brain, demonstrating that exercise at an advanced age, combined with the consumption of antioxidants, could produce favorable effects in terms of brain health.
eng
Physical activity
Memory
Monoamines
SIRT1
Brain health
Aging
Catechin
5-HT
Noradrenaline (NA)
Dopamine (DA)
Neurochemical and Cognitive Beneficial Effects of Moderate Physical Activity and Catechin in Aged Rats
research article