2026-04-29T22:57:45Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/232842024-11-29T02:15:52Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967

00925njm 22002777a 4500 dc Koss-Mikolajczyk, Izabela author Todorovic, Vanja author Sobajic, Sladjana author Mahajna, Jamal author Geric, Marko author Tur, Josep A author Bartoszek, Agnieszka author 2021-09 Cardiotoxicity is a frequent undesirable phenomenon observed during oncological treatment that limits the therapeutic dose of antitumor drugs and thus may decrease the effectiveness of cancer eradication. Almost all antitumor drugs exhibit toxic properties towards cardiac muscle. One of the underlying causes of cardiotoxicity is the stimulation of oxidative stress by chemotherapy. This suggests that an appropriately designed diet or dietary supplements based on edible plants rich in antioxidants could decrease the toxicity of antitumor drugs and diminish the risk of cardiac failure. This comprehensive review compares the cardioprotective efficacy of edible plant extracts and foodborne phytochemicals whose beneficial activity was demonstrated in various models in vivo and in vitro. The studies selected for this review concentrated on a therapy frequently applied in cancer, anthracycline antibiotic-doxorubicin-as the oxidative stress- and cardiotoxicity-inducing agent. Koss-Mikolajczyk I, Todorovic V, Sobajic S, Mahajna J, Geric M, Tur JA, et al. Natural Products Counteracting Cardiotoxicity during Cancer Chemotherapy: The Special Case of Doxorubicin, a Comprehensive Review. Int J Mol Sci. 2021 Sep;22(18):10037. 10.3390/ijms221810037 1422-0067 International Journal of Molecular Sciences https://hdl.handle.net/20.500.13003/19704 34576204 L2013790682 2-s2.0-85115063451 https://hdl.handle.net/20.500.12105/23284 699607500001 Cardiotoxicity Cardioprotectants Phytochemicals Antioxidants Anthracyclines Natural Products Counteracting Cardiotoxicity during Cancer Chemotherapy: The Special Case of Doxorubicin, a Comprehensive Review