2026-08-29T19:28:13Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/232832024-11-28T20:18:12Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967
Repisalud
author
Castillo, Pedro
author
Palou, Mariona
author
Yau-Qiu, Zhi Xin
author
Rodriguez, Ana M
author
Palou, Andreu
author
Picó, Catalina
2024-09-18T06:43:47Z
2024-09-18T06:43:47Z
2021-09
Castillo P, Palou M, Yau-Qiu ZX, Rodriguez AM, Palou A, Pico C. Myo-Inositol Supplementation in Suckling Rats Protects against Adverse Programming Outcomes on Hypothalamic Structure Caused by Mild Gestational Calorie Restriction, Partially Comparable to Leptin Effects. Nutrients. 2021 Sep;13(9):3257.
10.3390/nu13093257
2072-6643
Nutrients
https://hdl.handle.net/20.500.13003/19701
34579137
L2013790157
2-s2.0-85115117498
https://hdl.handle.net/20.500.12105/23283
700147600001
We studied whether myo-inositol supplementation throughout lactation, alone and combined with leptin, may reverse detrimental effects on hypothalamic structure and function caused by gestational calorie gestation (CR) in rats. Candidate early transcript-based biomarkers of metabolic health in peripheral blood mononuclear cells (PBMC) were also studied. offspring of dams exposed to 25% gestational CR and supplemented during lactation with physiological doses of leptin (CR-L), myo-inositol (CR-M), the combination (CR-LM), or the vehicle (CR-V) as well as control rats (CON-V) were followed and sacrificed at postnatal day 25. Myo-inositol and the combination increased the number of neurons in arcuate nucleus (ARC) (only in females) and paraventricular nucleus, and myo-inositol (alone) restored the number of alpha MSH+ neurons in ARC. Hypothalamic mRNA levels of Lepr in CR-M and Insr in CR-M and CR-LM males were higher than in CR-V and CON-V, respectively. In PBMC, increased expression levels of Lrp11 and Gls in CR-V were partially normalized in all supplemented groups (but only in males for Gls). Therefore, myo-inositol supplementation throughout lactation, alone and combined with leptin, reverts programmed alterations by fetal undernutrition on hypothalamic structure and gene expression of potential early biomarkers of metabolic health in PBMC, which might be attributed, in part, to increased leptin sensitivity.
eng
Fetal undernutrition
Myo-inositol
Leptin
Lactation period
Metabolic programming
Arcuate nucleus
Paraventricular nucleus
PBMC
Myo-Inositol Supplementation in Suckling Rats Protects against Adverse Programming Outcomes on Hypothalamic Structure Caused by Mild Gestational Calorie Restriction, Partially Comparable to Leptin Effects
research article