2026-05-17T01:44:08Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/232772024-11-28T17:29:48Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16961col_20.500.12105_16967col_20.500.12105_16968col_20.500.12105_16983

00925njm 22002777a 4500 dc Ribo-Coll, Margarita author Castro-Barquero, Sara author Lassale, Camille author Sacanella, Emilio author Ros, Emilio author Toledo, Estefanía author Sorli, Jose V author Diaz-Lopez, Andres author Lapetra, Jose author Muñoz-Bravo, Carlos author Aros, Fernando author Fiol Sala, Miquel author Serra-Majem, Lluis author Pinto, Xavier author Castaner, Olga author Fernandez-Lazaro, Cesar, I author Portoles, Olga author Babio, Nancy author Estruch, Ramon author Hernaez, Alvaro author 2021-03 Our aim was to assess whether long-term adherence to a Mediterranean diet (MedDiet) and leisure-time physical activity (LTPA) were associated with a lower initiation of cardiovascular drug use. We studied the association between cumulative average of MedDiet adherence and LTPA and the risk of cardiovascular drug initiation in older adults at high cardiovascular risk (PREvencion con DIeta MEDiterranea trial participants) non-medicated at baseline: glucose-lowering drugs (n = 4437), antihypertensives (n = 2145), statins (n = 3977), fibrates (n = 6391), antiplatelets (n = 5760), vitamin K antagonists (n = 6877), antianginal drugs (n = 6837), and cardiac glycosides (n = 6954). One-point increases in MedDiet adherence were linearly associated with a decreased initiation of glucose-lowering (HR: 0.76 [0.71-0.80]), antihypertensive (HR: 0.79 [0.75-0.82]), statin (HR: 0.82 [0.78-0.85]), fibrate (HR: 0.78 [0.68-0.89]), antiplatelet (HR: 0.79 [0.75-0.83]), vitamin K antagonist (HR: 0.83 [0.74; 0.93]), antianginal (HR: 0.84 [0.74-0.96]), and cardiac glycoside therapy (HR: 0.69 [0.56-0.84]). LTPA was non-linearly related to a delayed initiation of glucose-lowering, antihypertensive, statin, fibrate, antiplatelet, antianginal, and cardiac glycoside therapy (minimum risk: 180-360 metabolic equivalents of task-min/day). Both combined were synergistically associated with a decreased onset of glucose-lowering drugs (p-interaction = 0.04), antihypertensive drugs (p-interaction < 0.001), vitamin K antagonists (p-interaction = 0.04), and cardiac glycosides (p-interaction = 0.01). Summarizing, sustained adherence to a MedDiet and LTPA were associated with lower risk of initiating cardiovascular-related medications. Ribo-Coll M, Castro-Barquero S, Lassale C, Sacanella E, Ros E, Toledo E, et al. Mediterranean Diet and Physical Activity Decrease the Initiation of Cardiovascular Drug Use in High Cardiovascular Risk Individuals: A Cohort Study. Antioxidants. 2021 Mar;10(3):397. 10.3390/antiox10030397 2076-3921 Antioxidants https://hdl.handle.net/20.500.13003/19685 33808041 2-s2.0-85102050342 https://hdl.handle.net/20.500.12105/23277 633320700001 Mediterranean diet Physical activity Glucose-lowering drugs Antihypertensive drugs Statins Fibrates Antiplatelet drugs Vitamin K epoxide reductase inhibitors Antianginal drugs Cardiac glycosides Mediterranean Diet and Physical Activity Decrease the Initiation of Cardiovascular Drug Use in High Cardiovascular Risk Individuals: A Cohort Study