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oai:repisalud.isciii.es:20.500.12105/232702024-11-29T02:17:22Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967

00925njm 22002777a 4500 dc Bestard-Escalas, Joan author Reigada, Rebeca author Reyes Moreno, Jose author de la Torre, Paloma author Liebisch, Gerhard author Barcelo-Coblijn, Gwendolyn author 2021-05 Even though colorectal cancer (CRC) is one of the most preventable cancers, it is currently one of the deadliest. Worryingly, incidence in people <50 years has increased unexpectedly, and for unknown causes, despite the successful implementation of screening programs in the population aged >50 years. Thus, there is a need to improve early diagnosis detection strategies by identifying more precise biomarkers. In this scenario, the analysis of exosomes is given considerable attention. Previously, we demonstrated the exosome lipidome was able to classify CRC cell lines according to their malignancy. Herein, we investigated the use of the lipidome of plasma extracellular vesicles as a potential source of non-invasive biomarkers for CRC. A plasma exosome-enriched fraction was analyzed from patients undergoing colonoscopic procedure. Patients were divided into a healthy group and four pathological groups (patients with hyperplastic polyps; adenomatous polyps; invasive neoplasia (CRC patients); or hereditary non-polyposis CRC. The results showed a shift from 34:1- to 38:4-containing species in the pathological groups. We demonstrate that the ratio Sigma 34:1-containing species/Sigma 38:4-containing species has the potential to discriminate between healthy and pathological patients. Altogether, the results reinforce the utility of plasma exosome lipid fingerprint to provide new non-invasive biomarkers in a clinical context. Bestard-Escalas J, Reigada R, Reyes J, de la Torre P, Liebisch G, Barcelo-Coblijn G. Fatty Acid Unsaturation Degree of Plasma Exosomes in Colorectal Cancer Patients: A Promising Biomarker. Int J Mol Sci. 2021 May;22(10):5060. 10.3390/ijms22105060 1422-0067 International Journal of Molecular Sciences https://hdl.handle.net/20.500.13003/19597 34064646 L2007173014 2-s2.0-85105702258 https://hdl.handle.net/20.500.12105/23270 661993000001 Exosomes Lipidome Colorectal cancer Monounsaturated fatty acids Polyunsaturated fatty acids Fatty Acid Unsaturation Degree of Plasma Exosomes in Colorectal Cancer Patients: A Promising Biomarker