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oai:repisalud.isciii.es:20.500.12105/232652024-11-29T00:34:57Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967

00925njm 22002777a 4500 dc Martinez-Bernabe, Toni author Sastre-Serra, Jorge author Ciobu, Nicolae author Oliver, Jordi author Pons, Daniel-Gabriel author Roca, Pilar author 2021-09 Obesity, a physiological situation where different proinflammatory cytokines and hormones are secreted, is a major risk factor for breast cancer. Mitochondrial functionality exhibits a relevant role in the tumorigenic potential of a cancer cell. In the present study, it has been examined the influence of an obesity-related inflammation ELIT treatment (17 beta-estradiol, leptin, IL-6, and TNF alpha), which aims to stimulate the hormonal conditions of a postmenopausal obese woman on the mitochondrial functionality and invasiveness of MCF7 and T47D breast cancer cell lines, which display a different ratio of both estrogen receptor isoforms, ER alpha and ER beta. The results showed a decrease in mitochondrial functionality, with an increase in oxidative stress and invasiveness and motility, in the MCF7 cell line (high ER alpha/ER beta ratio) compared to a maintained status in the T47D cell line (low ER alpha/ER beta ratio) after ELIT treatment. In addition, breast cancer biopsies were analyzed, showing that breast tumors of obese patients present a high positive correlation between IL-6 receptor and ER beta and have an increased expression of cytokines, antioxidant enzymes, and mitochondrial biogenesis and dynamics genes. Altogether, giving special importance to ER beta in the pathology of obese patients with breast cancer is necessary, approaching to personalized medicine. Martinez-Bernabe T, Sastre-Serra J, Ciobu N, Oliver J, Pons DG, Roca P. Estrogen Receptor Beta (ER beta) Maintains Mitochondrial Network Regulating Invasiveness in an Obesity-Related Inflammation Condition in Breast Cancer. Antioxidants. 2021 Sep;10(9):1371. 10.3390/antiox10091371 2076-3921 Antioxidants https://hdl.handle.net/20.500.13003/19580 34573003 2-s2.0-85113846650 https://hdl.handle.net/20.500.12105/23265 699306100001 Obesity-related inflammation Oxidative stress Mitochondrial biogenesis Mitochondrial dynamics Epithelial-to-mesenchymal transition (EMT) Estrogen receptor beta (ER beta) Breast cancer Estrogen Receptor Beta (Erβ) Maintains Mitochondrial Network Regulating Invasiveness in an Obesity-Related Inflammation Condition in Breast Cancer