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oai:repisalud.isciii.es:20.500.12105/232642024-11-29T03:22:57Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967

00925njm 22002777a 4500 dc Martinez-Cignoni, Melanie Raquel author Gonzalez-Vicens, Agusti author Moran-Costoya, Andrea author Proenza, Ana Maria author Gianotti, Magdalena author Valle, Adamo author Lladó, Isabel author 2021-12 It has been reported that 17 beta-estradiol (E2) can exert beneficial effects against the development of obesity, providing women with a healthier metabolic profile and conferring cardiovascular protection. However, a growing body of evidence questions this role in the context of obesity and diabetes. We focus on the adipose tissue-heart axis to address the question of whether E2 can have metabolically detrimental effects in an obese-diabetic rat model. Female Zucker Diabetic Fatty rats were used: LEAN, fa/+; SHAM, sham-operated fa/fa; OVA, ovariectomized fa/fa, and OVA+E2, ovariectomized and E2 treated fa/fa. The secretory expression profile, tissue expansion parameters and composition of visceral adipose tissue, as well as systemic and cardiac parameters related to insulin resistance, fibrosis, and inflammation were analyzed. Ovariectomy induced an attenuation of both diabetic condition and metabolic dysfunction of adipose tissue and cardiac muscle in fa/fa rats, suggesting that E2, in the context of diabetes and obesity, loses its cardioprotective role and could even contribute to greater metabolic alterations. Adipose tissue from OVA rats showed a healthier hyperplastic expansion pattern, which could help maintain tissue function, increase adiponectin expression, and decrease pro-inflammatory adipokines. These findings should be taken into account when considering hormone replacement therapy for obese-diabetic women. Martinez-Cignoni MR, Gonzalez-Vicens A, Moran-Costoya A, Proenza AM, Gianotti M, Valle A, et al. Estrogen Impairs Adipose Tissue Expansion and Cardiometabolic Profile in Obese-Diabetic Female Rats. Int J Mol Sci. 2021 Dec;22(24):13573. 10.3390/ijms222413573 1422-0067 International Journal of Molecular Sciences https://hdl.handle.net/20.500.13003/19579 34948369 L2014936607 2-s2.0-85121300021 https://hdl.handle.net/20.500.12105/23264 738543400001 Diabesity Adipose tissue Tissue remodeling Estrogen ovariectomy Cardiometabolic alterations Inflammation Estrogen Impairs Adipose Tissue Expansion and Cardiometabolic Profile in Obese-Diabetic Female Rats