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oai:repisalud.isciii.es:20.500.12105/232622024-11-28T19:30:39Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967
Repisalud author Abbate, Manuela author Mascaro, Catalina M author Montemayor, Sofia author Barberia-Latasa, Maria author Casares, Miguel author Gómez Bellvert, Cristina author Angullo-Martinez, Escarlata author Tejada Gavela, Silvia author Abete, Itziar author Zulet, Maria Angeles author Sureda Gomila, Antoni author Alfredo Martinez, J author Tur, Josep A 2024-09-18T06:43:39Z 2024-09-18T06:43:39Z 2021-02 Abbate M, Mascaro CM, Montemayor S, Barberia-Latasa M, Casares M, Gomez C, et al. Energy Expenditure Improved Risk Factors Associated with Renal Function Loss in NAFLD and MetS Patients. Nutrients. 2021 Feb;13(2):629. 10.3390/nu13020629 2072-6643 Nutrients https://hdl.handle.net/20.500.13003/19573 33672073 L2006018965 2-s2.0-85100753283 https://hdl.handle.net/20.500.12105/23262 622948900001 To assess the efficacy of three lifestyle interventions on the reduction of liver fat content and metabolic syndrome (MetS), and whether such reductions would influence renal outcomes, we conducted a randomized controlled trial on 128 participants with MetS and non-alcoholic fatty liver disease (NAFLD), as well as available data on estimated glomerular filtration rate (eGFR) and urinary albumin-to-creatine ratio (UACR). Patients were randomized in 1:1:1 ratio to either Conventional Diet, Mediterranean diet (MD)-high meal frequency, and MD-physical activity groups. Each intervention aimed at reducing caloric intake by 25%-30% of baseline intake and increase energy expenditure by 400 kcal/70 kg. Patients attended regular visits and were followed-up for 6 months. Increased albuminuria was present in 13.3% of patients, while 32.8% showed hyperfiltration. UACR reduction was associated with higher levels of UACR at baseline but not with changes in liver fat. eGFR decreased in patients presenting hyperfiltration at baseline and was associated with reduction in liver fat and insulin resistance, as well as with increase in energy expenditure (R-2 = 0.248, p = 0.006). No significant differences were observed between the three treatment groups. In patients with NAFLD and MetS, energy expenditure significantly reduced hepatic fat accumulation and insulin resistance, which reduced glomerular hyperfiltration. Increased albuminuria was reduced, but it was not associated with reduced liver fat. eng Glomerular hyperfiltration Albumin-to-creatinine ratio non-alcoholic fatty liver disease Caloric restriction Increased energy expenditure Energy Expenditure Improved Risk Factors Associated with Renal Function Loss in NAFLD and MetS Patients research article