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Repisalud author Ramis, Margarita R author Sarubbo, Fiorella author Moranta, David author Tejada Gavela, Silvia author Llado, Jeronia author Miralles, Antonio author Esteban, Susana 2024-09-18T06:43:36Z 2024-09-18T06:43:36Z 2021-01 Ramis MR, Sarubbo F, Moranta D, Tejada S, Llado J, Miralles A, et al. Cognitive and Neurochemical Changes Following Polyphenol-Enriched Diet in Rats. Nutrients. 2021 Jan;13(1):59. 10.3390/nu13010059 2072-6643 Nutrients https://hdl.handle.net/20.500.13003/19507 33375450 L2005690812 2-s2.0-85098624526 https://hdl.handle.net/20.500.12105/23252 611081700001 Dietary recommendations are frequently developed based on nutrient deficiency or prevention of disease, but less attention has been paid to the dietary guidelines to promote brain health. Active and healthy aging is a prerequisite for improving quality of life as people age, and evidence is establishing a relationship between diet and brain health. This work studied the effect of a diet based on foods rich in antioxidants, especially polyphenols, in rats, three days a week for 20 months starting at 14 months. Behavioral analysis testing working memory, spatial and episodic memory, as well as brain monoaminergic neurotransmitters involved in these processes but also in general brain health were analyzed. In addition, hippocampal SIRT1 protein which has an important role in regulating normal brain function was evaluated. The results show that long-term intake of polyphenol-enriched diet improves memory and learning, correlating with restoration of brain monoaminergic neurotransmitters and hippocampal SIRT1 levels in aged rats. These results agree with reports revealing a neuroprotective effect of different polyphenolic compounds on age-related brain decline, based on its antioxidant and anti-inflammatory properties; and demonstrate that consumption of antioxidant-rich foods, a few days a week, gives good long-term results in terms of brain health. eng Memory Monoamines SIRT1 Dietary polyphenols Brain health Aging Antioxidant 5-HT NA DA Cognitive and Neurochemical Changes Following Polyphenol-Enriched Diet in Rats research article