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oai:repisalud.isciii.es:20.500.12105/232432024-11-28T20:10:43Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967
Repisalud author Mentis, Alexios-Fotios A author Garcia, Irene author Jimenez, Juan author Paparoupa, Maria author Xirogianni, Athanasia author Papandreou, Anastasia author Tzanakaki, Georgina 2024-09-18T06:43:34Z 2024-09-18T06:43:34Z 2021-04 Mentis AFA, Garcia I, Jimenez J, Paparoupa M, Xirogianni A, Papandreou A, et al. Artificial Intelligence in Differential Diagnostics of Meningitis: A Nationwide Study. Diagnostics. 2021 Apr;11(4):602. 10.3390/diagnostics11040602 2075-4418 Diagnostics https://hdl.handle.net/20.500.13003/19446 33800653 L2007655223 2-s2.0-85109021139 https://hdl.handle.net/20.500.12105/23243 642969200001 Differential diagnosis between bacterial and viral meningitis is crucial. In our study, to differentiate bacterial vs. viral meningitis, three machine learning (ML) algorithms (multiple logistic regression (MLR), random forest (RF), and naive-Bayes (NB)) were applied for the two age groups (0-14 and >14 years) of patients with meningitis by both conventional (culture) and molecular (PCR) methods. Cerebrospinal fluid (CSF) neutrophils, CSF lymphocytes, neutrophil-to-lymphocyte ratio (NLR), blood albumin, blood C-reactive protein (CRP), glucose, blood soluble urokinase-type plasminogen activator receptor (suPAR), and CSF lymphocytes-to-blood CRP ratio (LCR) were used as predictors for the ML algorithms. The performance of the ML algorithms was evaluated through a cross-validation procedure, and optimal predictions of the type of meningitis were above 95% for viral and 78% for bacterial meningitis. Overall, MLR and RF yielded the best performance when using CSF neutrophils, CSF lymphocytes, NLR, albumin, glucose, gender, and CRP. Also, our results reconfirm the high diagnostic accuracy of NLR in the differential diagnosis between bacterial and viral meningitis. eng Meningitis Bacterial infection Viral infection Neutrophil-to-lymphocyte ratio Artificial intelligence Machine learning Artificial Intelligence in Differential Diagnostics of Meningitis: A Nationwide Study research article