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oai:repisalud.isciii.es:20.500.12105/232392024-11-29T06:53:55Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967

00925njm 22002777a 4500 dc Abbate, Manuela author Montemayor, Sofia author Mascaro, Catalina M author Casares, Miguel author Gómez Bellvert, Cristina author Ugarriza, Lucia author Tejada Gavela, Silvia author Abete, Itziar author Zulet, Maria Angeles author Sureda Gomila, Antoni author Alfredo Martinez, J author Tur, Josep A author 2021-07 Background: Increased albuminuria is associated with increased serum ferritin, insulin resistance, and non-alcoholic fatty liver disease (NAFLD). Liver iron accumulation is also related to hyperferritinemia, insulin resistance, and NAFLD; however, there is no evidence on its relationship with albuminuria. Aims: To assess the relationship between hepatic iron load and urine albumin-to-creatinine ratio (UACR) in patients with metabolic syndrome (MetS) and NAFLD. Methods: In total, 75 MetS and NAFLD patients (aged 40-60 years, BMI 27-40 kg/m(2)) were selected from a cohort according to available data on hepatic iron load (HepFe) by magnetic resonance imaging (MRI). Subjects underwent anthropometric measurements, biochemistry testing, and liver MRI. Increased albuminuria was defined by UACR. Results: UACR correlated with NAFLD, HepFe, triglycerides, serum ferritin, fasting insulin, insulin resistance (calculated using the homeostatic model assessment for insulin resistance-HOMA-IR- formula), and platelets (p < 0.05). Multiple regression analysis adjusted for gender, age, eGFR, HbA1c, T2DM, and stages of NAFLD, found that HepFe (p = 0.02), serum ferritin (p = 0.04), fasting insulin (p = 0.049), and platelets (p = 0.009) were associated with UACR (R-2 = 0.370; p = 0.007). UACR, liver fat accumulation, serum ferritin, and HOMA-IR increased across stages of HepFe (p < 0.05). Patients with severe NAFLD presented higher HepFe, fasting insulin, HOMA-IR, and systolic blood pressure as compared to patients in NAFLD stage 1 (p < 0.05). Conclusion: Hepatic iron load, serum ferritin, fasting insulin, and platelets were independently associated with albuminuria. In the context of MetS, increased stages of NAFLD presented higher levels of HepFe. Higher levels of HepFe were accompanied by increased serum ferritin, insulin resistance, and UACR. The association between iron accumulation, MetS, and NAFLD may represent a risk factor for the development of increased albuminuria. Abbate M, Montemayor S, Mascaro CM, Casares M, Gomez C, Ugarriza L, et al. Albuminuria Is Associated with Hepatic Iron Load in Patients with Non-Alcoholic Fatty Liver Disease and Metabolic Syndrome. J Clin Med. 2021 Jul;10(14):3187. 10.3390/jcm10143187 2077-0383 Journal of Clinical Medicine https://hdl.handle.net/20.500.13003/19431 34300354 L2007850248 2-s2.0-85114075733 https://hdl.handle.net/20.500.12105/23239 676335800001 Albuminuria non-alcoholic fatty liver disease Hepatic iron load Fasting insulin Serum ferritin Platelet count Insulin resistance Metabolic syndrome Albuminuria Is Associated with Hepatic Iron Load in Patients with Non-Alcoholic Fatty Liver Disease and Metabolic Syndrome