2026-05-17T00:18:38Zhttps://repisalud.isciii.es/rest/oai/request
oai:repisalud.isciii.es:20.500.12105/232312024-11-28T23:24:46Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967
Repisalud author Capó Fiol, Xavier author Martorell, Miquel author Tur, Josep A author Sureda Gomila, Antoni author Pons, Antoni 2024-09-18T06:42:49Z 2024-09-18T06:42:49Z 2021-12 Capo X, Martorell M, Tur JA, Sureda A, Pons A. 5-Dodecanolide, a Compound Isolated from Pig Lard, Presents Powerful Anti-Inflammatory Properties. Molecules. 2021 Dec;26(23):7363. 10.3390/molecules26237363 1420-3049 Molecules https://hdl.handle.net/20.500.13003/19398 34885945 L636870762 2-s2.0-85121131008 https://hdl.handle.net/20.500.12105/23231 734538100001 Background: Pork lard (PL) is traditionally used as an anti-inflammatory agent. We propose to demonstrate the anti-inflammatory properties of PL, and elucidate which compounds could be responsible for the anti-inflammatory effects. Methods: The anti-inflammatory effects of PL were tested in a rat model of zymosan-induced hind paw inflammation. Further, the hydroalcoholic extract from PL was obtained, the composition analyzed, and the anti-inflammatory activity of the extracts and isolated components assayed using immune cells stimulated with lipopolysaccharide (LPS). Results: Applying the ointment on the inflamed rat feet reduced the foot diameter, foot weight, and activities of antioxidant enzymes and inflammatory markers of circulating neutrophils. The main components of the hydroalcoholic extract were 5-dodecanolide, oleamide, hexadecanoic acid, 9-octadecenoic acid, hexadecanamide, and resolvin D1. Conclusions: PL reduces the immune response in an animal model stimulated with zymosan. Hydroalcoholic PL extract and its components (5-Dodecanolide, Oleamide, and Resolvin D1) exerted an anti-inflammatory effect on LPS-stimulated neutrophils and peripheral mononuclear cells reducing the capability to produce TNF alpha, as well as the activities of antioxidant and pro-inflammatory enzymes. These effects are attributable to 5-dodecanolide, although the effects of this compound alone do not reach the magnitude of the anti-inflammatory effects observed by the complete hydroalcoholic extract. eng Pig lard Inflammation 5-dodecanolide Lipid mediators 5-Dodecanolide, a Compound Isolated from Pig Lard, Presents Powerful Anti-Inflammatory Properties research article