2026-07-21T11:29:20Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/232292024-09-22T04:55:52Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967
Repisalud
author
Lorente-Herce, Jose M
author
Parra-Membrives, Pablo
author
Martinez-Baena, Dario
author
Canete-Gomez, Jesus
author
Segura-Sampedro, Juan J
2024-09-18T06:42:48Z
2024-09-18T06:42:48Z
2021-09
Lorente-Herce JM, Parra-Membrives P, Martinez-Baena D, Canete-Gomez J, Segura-Sampedro JJ. Influence of surgical site infection on oncological prognosis after curative resection for colorectal cancer: An observational single-institution study. Cir Cir. 2021 Sep-Dec;89(5):574-82.
10.24875/CIRU.20000603
0009-7411
Cirugia y Cirujanos
https://hdl.handle.net/20.500.13003/19652
34665164
L2015288101
2-s2.0-85118592614
https://hdl.handle.net/20.500.12105/23229
707058700002
Background: An exacerbated inflammatory response to post-operative infection could favor an environment in which residual viable tumor cells present in the surgical bed, bloodstream, or occult micrometastases can survive and progress to produce local or distant recurrence. In this regard, a surgical site infection (SSI) could be an important risk factor for disease progression. This study aimed to investigate the impact of SSI on long-term survival and recurrence of colorectal cancer. Methods: Patients who underwent curative-intent resection for colorectal carcinoma between 2011 and 2013 were retrospectively analyzed. Overall and disease-free survival (DFS) and local recurrence rate for patients with and without SSI were analyzed. Results: One hundred and thirty-eight patients were included in the study. Fifty-one (37%) patients showed SSI but revealed no differences in recurrence rate and overall survival compared with non-infected patients. However, the stratified analysis revealed that patients with an intra-abdominal abscess or an organ-space-infection showed a higher recurrence rate and a decreased 5-year overall and DFS. Conclusions: SSI may have an influence on the oncological prognosis and, therefore, could be considered a recurrence factor. Further multi-institutional studies are necessary to conclude a causal association.
eng
Surgical site infection
Colorectal cancer
Oncological prognosis
Influence of surgical site infection on oncological prognosis after curative resection for colorectal cancer: An observational single-institution study
research article