2026-08-29T14:55:24Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/232222024-11-28T20:39:48Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967
Repisalud
author
Alshehri, Mohammed M
author
Sharifi-Rad, Javad
author
Herrera-Bravo, Jesus
author
Jara, Evelyn L
author
Salazar, Luis A
author
Kregiel, Dorota
author
Uprety, Yadav
author
Akram, Muhammad
author
Iqbal, Mehwish
author
Martorell, Miquel
author
Torrens-Mas, Margalida
author
Pons, Daniel Gabriel
author
Dastan, Sevgi Durna
author
Cruz-Martins, Natalia
author
Ozdemir, Fethi Ahmet
author
Kumar, Manoj
author
Cho, William C
2024-09-18T06:42:42Z
2024-09-18T06:42:42Z
2021-09-10
Alshehri MM, Sharifi-Rad J, Herrera-Bravo J, Jara EL, Salazar LA, Kregiel D, et al. Therapeutic Potential of Isoflavones with an Emphasis on Daidzein. Oxidative Med Cell Longev. 2021 Sep 10;2021:6331630.
10.1155/2021/6331630
1942-0994
1942-0900
Oxidative Medicine and Cellular Longevity
https://hdl.handle.net/20.500.13003/19873
34539970
L2014746679
2-s2.0-85115813446
https://hdl.handle.net/20.500.12105/23222
697318600001
Daidzein is a phytoestrogen isoflavone found in soybeans and other legumes. The chemical composition of daidzein is analogous to mammalian estrogens, and it could be useful with a dual-directional purpose by substituting/hindering with estrogen and estrogen receptor (ER) complex. Hence, daidzein puts forth shielding effects against a great number of diseases, especially those associated with the control of estrogen, such as breast cancer, diabetes, osteoporosis, and cardiovascular disease. However, daidzein also has other ER-independent biological activities, such as oxidative damage reduction acting as an antioxidant, immune regulator as an anti-inflammatory agent, and apoptosis regulation, directly linked to its potential anticancer effects. In this sense, the present review is aimed at providing a deepen analysis of daidzein pharmacodynamics and its implications in human health, from its best-known effects alleviating postmenopausal symptoms to its potential anticancer and antiaging properties.
eng
Therapeutic Potential of Isoflavones with an Emphasis on Daidzein
review article