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oai:repisalud.isciii.es:20.500.12105/232222024-11-28T20:39:48Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967

00925njm 22002777a 4500 dc Alshehri, Mohammed M author Sharifi-Rad, Javad author Herrera-Bravo, Jesus author Jara, Evelyn L author Salazar, Luis A author Kregiel, Dorota author Uprety, Yadav author Akram, Muhammad author Iqbal, Mehwish author Martorell, Miquel author Torrens-Mas, Margalida author Pons, Daniel Gabriel author Dastan, Sevgi Durna author Cruz-Martins, Natalia author Ozdemir, Fethi Ahmet author Kumar, Manoj author Cho, William C author 2021-09-10 Daidzein is a phytoestrogen isoflavone found in soybeans and other legumes. The chemical composition of daidzein is analogous to mammalian estrogens, and it could be useful with a dual-directional purpose by substituting/hindering with estrogen and estrogen receptor (ER) complex. Hence, daidzein puts forth shielding effects against a great number of diseases, especially those associated with the control of estrogen, such as breast cancer, diabetes, osteoporosis, and cardiovascular disease. However, daidzein also has other ER-independent biological activities, such as oxidative damage reduction acting as an antioxidant, immune regulator as an anti-inflammatory agent, and apoptosis regulation, directly linked to its potential anticancer effects. In this sense, the present review is aimed at providing a deepen analysis of daidzein pharmacodynamics and its implications in human health, from its best-known effects alleviating postmenopausal symptoms to its potential anticancer and antiaging properties. Alshehri MM, Sharifi-Rad J, Herrera-Bravo J, Jara EL, Salazar LA, Kregiel D, et al. Therapeutic Potential of Isoflavones with an Emphasis on Daidzein. Oxidative Med Cell Longev. 2021 Sep 10;2021:6331630. 10.1155/2021/6331630 1942-0994 1942-0900 Oxidative Medicine and Cellular Longevity https://hdl.handle.net/20.500.13003/19873 34539970 L2014746679 2-s2.0-85115813446 https://hdl.handle.net/20.500.12105/23222 697318600001 Therapeutic Potential of Isoflavones with an Emphasis on Daidzein