2026-04-29T02:18:38Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/232202024-11-28T21:23:29Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967

00925njm 22002777a 4500 dc Sharifi-Rad, Javad author Quispe, Cristina author Imran, Muhammad author Rauf, Abdur author Nadeem, Muhammad author Gondal, Tanweer Aslam author Ahmad, Bashir author Atif, Muhammad author Mubarak, Mohammad S author Sytar, Oksana author Zhilina, Oxana Mihailovna author Garsiya, Ekaterina Robertovna author Smeriglio, Antonella author Trombetta, Domenico author Pons, Daniel-Gabriel author Martorell, Miquel author Cardoso, Susana M author Razis, Ahmad Faizal Abdull author Sunusi, Usman author Kamal, Ramla Muhammad author Rotariu, Lia Sanda author Butnariu, Monica author Docea, Anca Oana author Calina, Daniela author 2021-07-20 Genistein is an isoflavone first isolated from the brooming plant Dyer's Genista tinctoria L. and is widely distributed in the Fabaceae family. As an isoflavone, mammalian genistein exerts estrogen-like functions. Several biological effects of genistein have been reported in preclinical studies, such as the antioxidant, anti-inflammatory, antibacterial, and antiviral activities, the effects of angiogenesis and estrogen, and the pharmacological activities on diabetes and lipid metabolism. The purpose of this review is to provide up-to-date evidence of preclinical pharmacological activities with mechanisms of action, bioavailability, and clinical evidence of genistein. The literature was researched using the most important keyword genistein from the PubMed, Science, and Google Scholar databases, and the taxonomy was validated using The Plant List. Data were also collected from specialized books and other online resources. The main positive effects of genistein refer to the protection against cardiovascular diseases and to the decrease of the incidence of some types of cancer, especially breast cancer. Although the mechanism of protection against cancer involves several aspects of genistein metabolism, the researchers attribute this effect to the similarity between the structure of soy genistein and that of estrogen. This structural similarity allows genistein to displace estrogen from cellular receptors, thus blocking their hormonal activity. The pharmacological activities resulting from the experimental studies of this review support the traditional uses of genistein, but in the future, further investigations are needed on the efficacy, safety, and use of nanotechnologies to increase bioavailability and therapeutic efficacy. Sharifi-Rad J, Quispe C, Imran M, Rauf A, Nadeem M, Gondal TA, et al. Genistein: An Integrative Overview of Its Mode of Action, Pharmacological Properties, and Health Benefits. Oxidative Med Cell Longev. 2021 Jul 20;2021:3268136. 1942-0900 https://hdl.handle.net/20.500.13003/19602 https://hdl.handle.net/20.500.12105/23220 34336089 10.1155/2021/3268136 1942-0994 Oxidative Medicine and Cellular Longevity 2-s2.0-85112487796 683312200003 L2013958928 Genistein: An Integrative Overview of Its Mode of Action, Pharmacological Properties, and Health Benefits