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oai:repisalud.isciii.es:20.500.12105/232142024-11-28T17:51:09Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16961col_20.500.12105_16967col_20.500.12105_16983

00925njm 22002777a 4500 dc Casas-Recasens, Sandra author Mendoza, Nuria author Lopez-Giraldo, Alejandra author Garcia, Tamara author García-Cosío, Borja author Pascual-Guardia, Sergi author Acosta-Castro, Ady author Borras-Santos, Alicia author Gea, Joaquim author Garrabou, Gloria author Agusti, Alvar author Faner, Rosa author EARLY COPD and BIOMEPOC projects author 2021-11-24 Accelerated ageing is implicated in the pathogenesis of respiratory diseases as chronic obstructive pulmonary disease (COPD), but recent evidence indicates that the COPD can have roots early in life. Here we hypothesise that the accelerated ageing markers might have a role in the pathobiology of young COPD. The objective of this study was to compare two hallmarks of ageing, telomere length (TL), and mitochondrial DNA copy number (mtDNA-CN, as a surrogate marker of mitochondrial dysfunction) in young (<= 50 years) and old (>50 years) smokers, with and without COPD. Both, TL and mtDNA-CN were measured in whole blood DNA by quantitative PCR [qPCR] in: (1) young ever smokers with (n = 81) or without (n = 166) COPD; and (2) old ever smokers with (n = 159) or without (n = 29) COPD. A multivariable linear regression was used to assess the association of TL and mtDNA-CN with lung function. We observed that in the entire study population, TL and mtDNA-CN decreased with age, and the former but not the latter related to FEV1/FVC (%), FEV1 (% ref.), and DLCO (% ref.). The short telomeres were found both in the young and old patients with severe COPD (FEV1 <50% ref.). In addition, we found that TL and mtDNA-CN were significantly correlated, but their relationship was positive in younger while negative in the older patients with COPD, suggesting a mitochondrial dysfunction. We conclude that TL, but not mtDNA-CN, is associated with the lung function impairment. Both young and old patients with severe COPD have evidence of accelerated ageing (shorter TL) but differ in the direction of the correlation between TL and mtDNA-CN in relation to age. Casas-Recasens S, Mendoza N, Lopez-Giraldo A, Garcia T, Cosio BG, Pascual-Guardia S, et al. Telomere Length but Not Mitochondrial DNA Copy Number Is Altered in Both Young and Old COPD. Front Med. 2021 Nov 24;8:761767. https://hdl.handle.net/20.500.13003/19845 https://hdl.handle.net/20.500.12105/23214 34901077 10.3389/fmed.2021.761767 2296-858X Frontiers in Medicine 2-s2.0-85120857653 738319400001 L636593681 Telomeres Mitochondrial DNA Chronic bronchitis Emphysema Ageing Telomere Length but Not Mitochondrial DNA Copy Number Is Altered in Both Young and Old COPD