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00925njm 22002777a 4500 dc Alonso-Fernandez, Alberto author Ribot Quetglas, Caterina author Herranz Mochales, Andrea author Alvarez Ruiz De Larrinaga, Ainhoa author Sanchez Baron, Andres author Rodriguez Rodriguez, Paula author Gil Gomez, Ana Victoria author Martinez, Carla Pia author Cubero Marin, Jose Pablo author Barcelo Nicolau, Maria author Cerdá Moncadas, Maria author Codina Marcet, Mercedes author De La Pena Bravo, Monica author Barcelo Bennasar, Antonia author Iglesias Coma, Amanda author Morell Garcia, Daniel author Pena Zarza, Jose Antonio author Gimenez Carrero, Maria Paloma author Duran Cantolla, Joaquin author Marin Trigo, Jose Maria author Pinas Cebrian, Maria Concepcion author Soriano, Joan B author Garcia-Rio, Francisco author 2021-11-02 Background: Obstructive sleep apnea (OSA) is prevalent in pregnancy and it is associated with adverse pregnancy-related outcomes such as gestational diabetes, pre-eclampsia, and low birth weight. Maternal systemic inflammation is proposed to be one of the main intermediate mechanisms. However, the effects of OSA on systemic inflammation are unknown in normal pregnancy. Methods: Women in the 3rd trimester underwent hospital polysomnography to evaluate whether OSA increases systemic inflammation in normal pregnancy and its potential association with adverse fetal outcomes. OSA was defined as an apnea-hypopnea index (AHI) of >= 5 h(-1). Plasma cytokines levels (TNF-alpha, IL-1 beta, IL-6, IL-8, and IL-10) were determined by multiple immunoassays. Results: We included 11 patients with OSA and 22 women with AHI < 5 h(-1), who were homogeneous in age, and body mass index (BMI). Women with OSA had significant higher levels of TNF-alpha, IL-1 beta, IL-8, and IL-10. We found significant correlations between AHI during REM and TNF-alpha (r = 0.40), IL-1 beta (r = 0.36), IL-6 (r = 0.52), IL-8 (r = 0.43), between obstructive apnea index and TNF-alpha (r = 0.46) and between AHI and IL-1 beta (r = 0.43). We also found that CT90% was related to IL-8 (r = 0.37). There were no significant differences in neonatal characteristics; however, we found inverse correlations between TNF-alpha and IL-8 with birth weight (both r = -0.48), while IL-8 showed a significant inverse relationship with neonatal gestational age (r = -0.48). Conclusions: OSA in our normal pregnancy population was associated with higher systemic inflammation, which was related to obstructive events, especially during REM sleep. Moreover, systemic inflammation was inversely correlated with neonatal birth weight and age. Alonso-Fernandez A, Quetglas CR, Mochales AH, De Larrinaga AAR, Baron AS, Rodriguez PR, et al. Influence of Obstructive Sleep Apnea on Systemic Inflammation in Pregnancy. Front Med. 2021 Nov 2;8:674997. https://hdl.handle.net/20.500.13003/19651 https://hdl.handle.net/20.500.12105/23209 34796182 10.3389/fmed.2021.674997 2296-858X Frontiers in Medicine 2-s2.0-85119329857 719667400001 L636447302 Apneas-hypopneas index Hypoxia Fetal outcomes REM Cytokine Inflammation Obstructive sleep apnea Influence of Obstructive Sleep Apnea on Systemic Inflammation in Pregnancy