2026-04-29T04:52:11Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/231962024-11-29T01:12:11Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967
Repisalud
author
Terrasa, Juan Lorenzo
author
Montoya, Pedro
author
Sitges, Carolina
author
van der Meulen, Marian
author
Anton, Fernand
author
González-Roldán, Ana María
2024-09-18T06:42:23Z
2024-09-18T06:42:23Z
2021
Terrasa JL, Montoya P, Sitges C, van der Meulen M, Anton F, González-Roldán AM. Anterior Cingulate Cortex Activity During Rest Is Related to Alterations in Pain Perception in Aging. Front Aging Neurosci. 2021;13:695200.
1663-4365
http://hdl.handle.net/20.500.13003/18483
https://hdl.handle.net/20.500.12105/23196
34295241
10.3389/fnagi.2021.695200
Frontiers in aging neuroscience
2-s2.0-85111071721
674723700001
L635534572
Alterations in the affective component of pain perception are related to the development of chronic pain and may contribute to the increased vulnerability to pain observed in aging. The present study analyzed age-related changes in resting-state brain activity and their possible relation to an increased pain perception in older adults. For this purpose, we compared EEG current source density and fMRI functional-connectivity at rest in older (n = 20, 66.21 ± 3.08 years) and younger adults (n = 21, 20.71 ± 2.30 years) and correlated those brain activity parameters with pain intensity and unpleasantness ratings elicited by painful stimulation. We found an age-related increase in beta2 and beta3 activity in temporal, frontal, and limbic areas, and a decrease in alpha activity in frontal areas. Moreover, older participants displayed increased functional connectivity in the anterior cingulate cortex (ACC) and the insula with precentral and postcentral gyrus. Finally, ACC beta3 activity was positively correlated with pain intensity and unpleasantness ratings in older, and ACC-precentral/postcentral gyrus connectivity was positively correlated with unpleasantness ratings in older and younger participants. These results reveal that ACC resting-state hyperactivity is a stable trait of brain aging and may underlie their characteristic altered pain perception.
eng
Aging
Pain
Brain activity
EEG
fMRI
Resting-state
Anterior cingulate cortex
Anterior Cingulate Cortex Activity During Rest Is Related to Alterations in Pain Perception in Aging
research article