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oai:repisalud.isciii.es:20.500.12105/231962024-11-29T01:12:11Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967

00925njm 22002777a 4500 dc Terrasa, Juan Lorenzo author Montoya, Pedro author Sitges, Carolina author van der Meulen, Marian author Anton, Fernand author González-Roldán, Ana María author 2021 Alterations in the affective component of pain perception are related to the development of chronic pain and may contribute to the increased vulnerability to pain observed in aging. The present study analyzed age-related changes in resting-state brain activity and their possible relation to an increased pain perception in older adults. For this purpose, we compared EEG current source density and fMRI functional-connectivity at rest in older (n = 20, 66.21 ± 3.08 years) and younger adults (n = 21, 20.71 ± 2.30 years) and correlated those brain activity parameters with pain intensity and unpleasantness ratings elicited by painful stimulation. We found an age-related increase in beta2 and beta3 activity in temporal, frontal, and limbic areas, and a decrease in alpha activity in frontal areas. Moreover, older participants displayed increased functional connectivity in the anterior cingulate cortex (ACC) and the insula with precentral and postcentral gyrus. Finally, ACC beta3 activity was positively correlated with pain intensity and unpleasantness ratings in older, and ACC-precentral/postcentral gyrus connectivity was positively correlated with unpleasantness ratings in older and younger participants. These results reveal that ACC resting-state hyperactivity is a stable trait of brain aging and may underlie their characteristic altered pain perception. Terrasa JL, Montoya P, Sitges C, van der Meulen M, Anton F, González-Roldán AM. Anterior Cingulate Cortex Activity During Rest Is Related to Alterations in Pain Perception in Aging. Front Aging Neurosci. 2021;13:695200. 1663-4365 http://hdl.handle.net/20.500.13003/18483 https://hdl.handle.net/20.500.12105/23196 34295241 10.3389/fnagi.2021.695200 Frontiers in aging neuroscience 2-s2.0-85111071721 674723700001 L635534572 Aging Pain Brain activity EEG fMRI Resting-state Anterior cingulate cortex Anterior Cingulate Cortex Activity During Rest Is Related to Alterations in Pain Perception in Aging