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oai:repisalud.isciii.es:20.500.12105/231932024-11-28T23:47:43Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967

00925njm 22002777a 4500 dc Pastor, Rosario author Bouzas, Cristina author Tur, Josep A author 2021-08-20 Background and aims: Olive oil and components might have a beneficial effect on Metabolic Syndrome (MetS). The aim of this review and meta-analysis was to assess whether those effects are related to hydroxytyrosol or oleic acid contents, or the combination of them as olive oil, and how powerful is this effect. Methods: A systematic literature search was performed in MEDLINE via Pubmed, Web of Science (WOS) core collection, and Virtual Health Library (VHL) via LILACS and IBECS (Spain). MeSH terms used were obesity, body weight, body mass index, adipose tissue, lipid metabolism, LDL, HDL, VLDL, insulin resistance, glucose, insulin, hypertension, arterial pressure, olive oil, oleic acid, and other (non-MeSH) terms: total antioxidant capacity, total antioxidant status, hydroxytyrosol (PROSPERO ID: CRD42021247614). Results of the included studies were meta-analyzed with the RevMan 5.3 program, assuming a random effects model. Results: 76 research articles (67 different trials) were identified. Hydroxytyrosol had no effect on MetS [combined standardized mean differences (SMD) = 0.01 (CI 95%: [-0.23, 0.25], I-2 = 83%; p = 0.920)]. Oleic acid had no significant beneficial effect on MetS [SMD = 0.03 (CI 95%: [-0.01, 0.07], I-2 = 0%); p = 0.150], but it improved lipid profile [SMD = 0.06 (CI 95%: [-0.00, 0.12], I-2 = 0%); p = 0. 050]. Olive oil had no effect on MetS [SMD =-0.01 (CI 95%: [-0.05, 0.03]), I-2 = 55%; p = 0.550)]. The supplementation with hydroxytyrosol, oleic acid or olive oil showed a beneficial effect on antioxidant capacity related to components of MetS [SMD = 0.31 (CI 95%: [-0.34, 0.95], I-2 = 81%)]; p = 0.35). Conclusion: Most research articles compared olive oil and oleic acid with other strategies specially designed for MetS management. Our findings suggest that olive oil or oleic acid consumption are as good as the other strategies to manage MetS. Pastor R, Bouzas C, Tur JA. Beneficial effects of dietary supplementation with olive oil, oleic acid, or hydroxytyrosol in metabolic syndrome: Systematic review and meta-analysis. Free Radic Biol Med. 2021 Aug 20;172:372-85. 10.1016/j.freeradbiomed.2021.06.017 1873-4596 0891-5849 Free Radical Biology and Medicine https://hdl.handle.net/20.500.13003/19464 34153478 L2013308520 2-s2.0-85108879573 https://hdl.handle.net/20.500.12105/23193 684984400002 Olive oil Oleic acid Hydroxytyrosol Metabolic syndrome Dyslipidemia Insulin resistance Hypertension Obesity Total antioxidant capacity Total antioxidant status Systematic review meta-Analysis Beneficial effects of dietary supplementation with olive oil, oleic acid, or hydroxytyrosol in metabolic syndrome: Systematic review and meta-analysis