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00925njm 22002777a 4500 dc Garcia-Cabrerizo, Ruben author Bis-Humbert, Cristian author García-Fuster, M Julia author 2021-09 Following methamphetamine consumption and during abstinence many behavioral consequences emerge (i.e., cognitive deficits, ongoing episodes of psychosis, depression, severe cravings, brain neurotoxicity), which are likely linked to propensity to relapse. In this line of thought, we recently showed that binge methamphetamine administration enhanced negative affect and voluntary drug consumption in rats, while it induced persistent neurotoxic effects (i.e., impaired hippocampal neurogenesis), effects that emerged long after drug removal. To date, no pharmacological strategies have been proven to be effective for the treatment of methamphetamine toxicity. A few studies have evaluated the impact of combining methamphetamine pretreatment with electroconvulsive seizures (ECS) post-treatment, an alternative non-pharmacological option used in psychiatry for resistant depression that offers a safe and really potent therapeutic response. Against this background, the present study aimed at testing whether repeated ECS treatment could ameliorate some of the long-term neurotoxicity effects induced by adolescent methamphetamine exposure in rats and emerging after drug removal. At the behavioral level, the main results showed that methamphetamine administration did not alter negative affect immediate during adolescence or later on in adulthood. Interestingly, repeated ECS improved the negative impact of methamphetamine administration on reducing hippocampal neurogenesis, demonstrating that ECS can attenuate certain degree of methamphetamine-induced neurotoxicity in rats, and suggesting ECS as a good therapeutical candidate that deserves further studies. Garcia-Cabrerizo R, Bis-Humbert C, Garcia-Fuster MJ. Electroconvulsive seizures protect against methamphetamine-induced inhibition of neurogenesis in the rat hippocampus. Neurotoxicology. 2021 Sep;86:185-91. 10.1016/j.neuro.2021.08.008 1872-9711 0161-813X Neurotoxicology https://hdl.handle.net/20.500.13003/19567 34418438 L2014160846 2-s2.0-85113630824 https://hdl.handle.net/20.500.12105/23177 696979300012 Electroconvulsive seizures Methamphetamine Forced abstinence Neurogenesis Rat Electroconvulsive seizures protect against methamphetamine-induced inhibition of neurogenesis in the rat hippocampus