2026-04-29T02:37:44Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/231682024-11-28T22:04:20Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967

00925njm 22002777a 4500 dc García-Cosío, Borja author Shafiek, Hanaa author Toledo Pons, Nuria author Iglesias, Amanda author Barcelo, Margalida author Represas-Represas, Cristina author Comeche, Lorena author Catalan, Pablo author Fernandez-Villar, Alberto author Lopez-Campos, Jose Luis author Echave-Sustaeta, Jose M author Soler-Cataluna, Juan Jose author 2021 Purpose: Exacerbations of COPD (ECOPD) are a frequent cause of hospitalization that seemed to ameliorate during the COVID outbreak. We aimed to evaluate the clinical characteristics of COPD-related hospital admissions and mortality in relation to the presence of COVID-19. Patients and Methods: We conducted a case-control study of patients admitted in four teaching hospitals throughout Spain between March 15 and April 30, 2020. Hospital admissions of respiratory cause with and without PCR-proven SARS-CoV-2 infection in patients with COPD were evaluated. Baseline and episode-related clinical characteristics were analyzed. Logistic regression analysis was performed to evaluate the risk for mortality. Results: During the study period, 2101 patients were admitted for respiratory worsening, 1200 (57.1%) with COVID-19. A total of 228 (10.8%) were admitted due to COPD worsening, of whom 52 (22.8%) tested positive for COVID-19. COPD patients with COVID-19, when compared to those without COVID-19, were more frequently males with better lung function (FEV1 postbronchodilator 71% vs 46% respectively, p<0.001) and had higher mortality (44.9% vs 13.6% respectively, p<0.001) despite similar age, comorbidities, total days of hospitalization and admission to intensive care unit. COVID-19 and eosinopenia were the strongest risk factors for mortality in the multivariate analysis in the overall COPD population. Inhaled corticosteroid use was not associated to mortality. Conclusion: Hospitalizations for ECOPD without COVID-19 were more frequent than COPD with COVID-19 during the first outbreak, but the latter were associated with higher mortality and low eosinophil counts that warrant further analysis. Cosio BG, Shafiek H, Toledo-Pons N, Iglesias A, Barcelo M, Represas-Represas C, et al. Characterization of COPD Admissions During the First COVID-19 Outbreak. Int J Chronic Obstr Pulm Dis. 2021;16:1549-54. 1178-2005 https://hdl.handle.net/20.500.13003/19487 https://hdl.handle.net/20.500.12105/23168 34113088 10.2147/COPD.S312493 International Journal of Chronic Obstructive Pulmonary Disease 2-s2.0-85108032821 662305300001 L2007504226 COPD exacerbation Mortality Inhaled corticosteroids Hospitalization Characterization of COPD Admissions During the First COVID-19 Outbreak