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00925njm 22002777a 4500 dc Laguna, Juan C author Alegret, Marta author Cofan, Montserrat author Sanchez-Tainta, Ana author Diaz-Lopez, Andres author Martinez-Gonzalez, Miguel A author V. Sorli, Jose author Salas-Salvado, Jordi author Fito, Montserrat author Alonso-Gomez, Angel M author Serra-Majem, Lluis author Laperra, Jose author Fiol Sala, Miquel author Gomez-Gracia, Enrique author Pinto, Xavier author Muñoz, Miguel A author Castaner, Olga author Ramirez-Sabio, Judith B author Portu, Jose J author Estruch, Ramon author Ros, Emilio author 2021-10 Objective: To examine associations between intake of simple sugars and cancer incidence, cancer mor-tality, and total mortality in a prospective cohort study based on the PREDIMED trial conducted from 2003 to 2010. Methods: Participants were older individuals at high cardiovascular risk. Exposures were total sugar, glucose and fructose from solid or liquid sources, and fructose from fruit and 100% fruit juice. Cancer incidence was the primary outcome; cancer mortality and all-cause mortality were secondary outcomes. Multivariable-adjusted, time-dependent Cox proportional hazard models were used. Results: of 7447 individuals enrolled, 7056 (94.7%) were included (57.6% women, aged 67.0 +/- 6.2 years). 534 incident cancers with 152 cancer deaths and 409 all-cause deaths were recorded after a median follow-up of 6 years. Intake of simple sugars in solid form was unrelated to outcomes. Higher cancer incidence was found per 5 g/day increase in intake of liquid sugars, with multivariable-adjusted HR of 1.08 (95% CI, 1.03-1.13) for total liquid sugar, 1.19 (95% CI, 1.07-1.31) for liquid glucose, 1.14 (95% CI, 1.05-1.23) for liquid fructose, and 1.39 (95% CI, 1.10-1.74) for fructose from fruit juice. Cancer and all-cause mortality increased to a similar extent with intake of all sugars in liquid form. In categorical models, cancer risk was dose-related for all liquid sugars. Conclusions: Simple sugar intake in drinks and fruit juice was associated with an increased risk of overall cancer incidence and mortality and all-cause mortality. This suggests that sugary beverages are a modifiable risk factor for cancer and all-cause mortality. (c) 2021 The Authors. Published by Elsevier Ltd. This is an open access research article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Laguna JC, Alegret M, Cofan M, Sanchez-Tainta A, Diaz-Lopez A, Martinez-Gonzalez MA, et al. Simple sugar intake and cancer incidence, cancer mortality and all- cause mortality: A cohort study from the PREDIMED trial. Clin Nutr. 2021 Oct;40(10):5269-77. 10.1016/j.clnu.2021.07.031 1532-1983 0261-5614 Clinical Nutrition https://hdl.handle.net/20.500.13003/19822 34536637 L2014578356 2-s2.0-85114954125 https://hdl.handle.net/20.500.12105/23160 706556800005 Observational study Dietary sugar Fructose Glucose Fruit juice Liquid form Simple sugar intake and cancer incidence, cancer mortality and all- cause mortality: A cohort study from the PREDIMED trial