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00925njm 22002777a 4500 dc Paz-Graniel, Indira author Becerra-Tomas, Nerea author Babio, Nancy author Serra-Majem, Lluis author Vioque, Jesus author Zomeño-Fajardo, María Dolores author Corella, Dolores author Pinto, Xavier author Bueno-Cavanillas, Aurora author Tur, Josep A author Daimiel, Lidia author Angeles Zulet, M author Palau-Galindo, Antoni author Torres-Collado, Laura author Schroder, Helmut author Gimenez-Alba, Ignacio Manuel author Nissenshon, Mariela author Galera, Ana author Riquelme-Gallego, Blanca author Bouzas, Cristina author Mico, Victor author Alfredo Martinez, J author Canudas, Silvia author Castaner, Olga author Vazquez-Ruiz, Zenaida author Salas-Salvado, Jordi author 2021-06 Background & aims: The association between drinking water consumption and adiposity has been poorly explored. Therefore, we aimed to analyse the associations between the frequency of drinking water consumption and body weight and waist circumference changes in an elderly Mediterranean cohort. Methods: A total of 1832 elderly participants (aged 55-75 years) with metabolic syndrome from the PREDIMED-Plus study with baseline data on drinking water and other beverages assessed by a validated 32-item Spanish fluid-intake questionnaire and with data on body weight (BW) and waist circumference (WC) at 1-year and 2-year were included in these prospective analyses. Multivariable linear regression models were fitted to assess the b-coefficients and 95% confidence interval (CI) for BW and WC changes in terms of categories of baseline drinking water consumption (tap water and bottled water). The theoretical effect on BW and WC of replacing several beverages with drinking water was assessed using mathematical models. Results: The baseline frequency of drinking water consumption was inversely associated with 1-year and 2 year changes in BW. b-coefficients (95%CI) across categories of water consumption (<2.5, 2.5 to <5, 5 to < 7.5, >7.5 servings/d) expressed in % of weight changes at 2 years of follow-up were 0.0,-0.80 (-1.48,-0.12),-1.36 (-2.18,-0.54), and-1.97 (-3.09,-0.86), respectively. Individuals in the two highest categories of drinking water consumption (5 to < 7, and >7.5 servings/d) also showed a higher decrease in WC (expressed as % of change) after 2 years of follow-up:-1.11 (-1.96,-0.25) and-1.45 (-2.66,-0.24) compared to the reference intake (<2.5 servings/day), after adjustment for potential confounding factors. The theoretical replacement of soups, beers, spirits, hot beverages, dairy beverages, and other beverages group with drinking water was associated with greater reductions in BW at one-and two-years of follow-up. Conclusions: Drinking water consumption was inversely associated with 2-year adiposity changes in an elderly Mediterranean cohort at high cardiovascular risk. Our results also suggest that the consumption of drinking water instead of energy-containing beverages is associated with lower weight gain. The trial registration: ISRCTN89898870. Paz-Graniel I, Becerra-Tomas N, Babio N, Serra-Majem L, Vioque J, Zomeno MD, et al. Baseline drinking water consumption and changes in body weight and waist circumference at 2-years of follow-up in a senior Mediterranean population. Clin Nutr. 2021 Jun;40(6):3982-3991. 10.1016/j.clnu.2021.05.014 1532-1983 0261-5614 Clinical Nutrition https://hdl.handle.net/20.500.13003/19462 34139471 L2013037557 2-s2.0-85107811925 https://hdl.handle.net/20.500.12105/23159 668759900040 Plain water Body weight Weight loss Central obesity Alcoholic beverages Sugary drinks Baseline drinking water consumption and changes in body weight and waist circumference at 2-years of follow-up in a senior Mediterranean population