2026-08-29T14:05:11Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/231582024-11-28T19:49:43Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967
Repisalud
author
Vreijling, Sarah R
author
Penninx, Brenda WJH
author
Bot, Mariska
author
Watkins, Ed
author
Owens, Matthew
author
Kohls, Elisabeth
author
Hegerl, Ulrich
author
Roca, Miquel
author
Gili, Margalida
author
Brouwer, Ingeborg A
author
Visser, Marjolein
author
Beekman, Aartjan TF
author
Jansen, Rick
author
Lamers, Femke
2024-09-18T06:42:04Z
2024-09-18T06:42:04Z
2021-04-07
Vreijling SR, Penninx BWJH, Bot M, Watkins E, Owens M, Kohls E, et al. Effects of dietary interventions on depressive symptom profiles: results from the MooDFOOD depression prevention study. Psychol Med. 2021 Apr 7;52(15):1-10.
10.1017/S0033291721000337
1469-8978
0033-2917
Psychological Medicine
https://hdl.handle.net/20.500.13003/19560
33823960
L634757999
2-s2.0-85103823296
https://hdl.handle.net/20.500.12105/23158
786855500001
Background: Dietary interventions did not prevent depression onset nor reduced depressive symptoms in a large multi-center randomized controlled depression prevention study (MooDFOOD) involving overweight adults with subsyndromal depressive symptoms. We conducted follow-up analyses to investigate whether dietary interventions differ in their effects on depressive symptom profiles (mood/cognition; somatic; atypical, energy-related). Methods: Baseline, 3-, 6-, and 12-month follow-up data from MooDFOOD were used (n = 933). Participants received (1) placebo supplements, (2) food-related behavioral activation (F-BA) therapy with placebo supplements, (3) multi-nutrient supplements (omega-3 fatty acids and a multi-vitamin), or (4) F-BA therapy with multi-nutrient supplements. Depressive symptom profiles were based on the Inventory of Depressive Symptomatology. Results: F-BA therapy was significantly associated with decreased severity of the somatic (B = -0.03, p = 0.014, d = -0.10) and energy-related (B = -0.08, p = 0.001, d = -0.13), but not with the mood/cognition symptom profile, whereas multi-nutrient supplementation was significantly associated with increased severity of the mood/cognition (B = 0.05, p = 0.022, d = 0.09) and the energy-related (B = 0.07, p = 0.002, d = 0.12) but not with the somatic symptom profile. Conclusions: Differentiating depressive symptom profiles indicated that food-related behavioral interventions are most beneficial to alleviate somatic symptoms and symptoms of the atypical, energy-related profile linked to an immuno-metabolic form of depression, although effect sizes were small. Multi-nutrient supplements are not indicated to reduce depressive symptom profiles. These findings show that attention to clinical heterogeneity in depression is of importance when studying dietary interventions.
eng
Diet
Depression prevention
Depressive symptom profiles
Heterogeneity
Effects of dietary interventions on depressive symptom profiles: results from the MooDFOOD depression prevention study
research article