2026-04-29T20:47:12Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/231212024-11-28T16:30:25Zcom_20.500.12105_2173com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19597col_20.500.12105_16938
Repisalud
author
Martínez-Illescas, Nuria G
author
Leal, Silvia
author
González, Patricia
author
Graña-Castro, Osvaldo
author
Muñoz-Oliveira, Juan José
author
Cortés-Peña, Alfonso
author
Gómez-Gil, María
author
Vega, Zaira
author
Neva, Verónica
author
Romero, Andrea
author
Quintela Fandino, Miguel Angel
author
Ciruelos, Eva
author
Sanz, Consuelo
author
Aragón, Sofía
author
Sotolongo, Leisy
author
Jiménez, Sara
author
Caleiras, Eduardo
author
Mulero, Francisca
author
Sánchez, Cristina
author
Malumbres, Marcos
author
Salazar-Roa, María
funder
Comunidad de Madrid (España)
funder
Ministerio de Ciencia, Innovación y Universidades (España)
funder
Asociación Española Contra el Cáncer
2024-09-16T08:17:13Z
2024-09-16T08:17:13Z
2023-08-04
Breast Cancer Res . 2023 ;25(1):91.
10.1186/s13058-023-01690-9
1465-542X
Breast cancer research : BCR
37542268
https://hdl.handle.net/20.500.12105/23121
A hallmark of many malignant tumors is dedifferentiated (immature) cells bearing slight or no resemblance to the normal cells from which the cancer originated. Tumor dedifferentiated cells exhibit a higher capacity to survive to chemo and radiotherapies and have the ability to incite tumor relapse. Inducing cancer cell differentiation would abolish their self-renewal and invasive capacity and could be combined with the current standard of care, especially in poorly differentiated and aggressive tumors (with worst prognosis). However, differentiation therapy is still in its early stages and the intrinsic complexity of solid tumor heterogeneity demands innovative approaches in order to be efficiently translated into the clinic. We demonstrate here that microRNA 203, a potent driver of differentiation in pluripotent stem cells (ESCs and iPSCs), promotes the differentiation of mammary gland tumor cells. Combining mouse in vivo approaches and both mouse and human-derived tridimensional organoid cultures, we report that miR-203 influences the self-renewal capacity, plasticity and differentiation potential of breast cancer cells and prevents tumor cell growth in vivo. Our work sheds light on differentiation-based antitumor therapies and offers miR-203 as a promising tool for directly confronting the tumor-maintaining and regeneration capability of cancer cells.
eng
miR-203 drives breast cancer cell differentiation
research article