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oai:repisalud.isciii.es:20.500.12105/231212024-11-28T16:30:25Zcom_20.500.12105_2173com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19597col_20.500.12105_16938

00925njm 22002777a 4500 dc Martínez-Illescas, Nuria G author Leal, Silvia author González, Patricia author Graña-Castro, Osvaldo author Muñoz-Oliveira, Juan José author Cortés-Peña, Alfonso author Gómez-Gil, María author Vega, Zaira author Neva, Verónica author Romero, Andrea author Quintela Fandino, Miguel Angel author Ciruelos, Eva author Sanz, Consuelo author Aragón, Sofía author Sotolongo, Leisy author Jiménez, Sara author Caleiras, Eduardo author Mulero, Francisca author Sánchez, Cristina author Malumbres, Marcos author Salazar-Roa, María author 2023-08-04 A hallmark of many malignant tumors is dedifferentiated (immature) cells bearing slight or no resemblance to the normal cells from which the cancer originated. Tumor dedifferentiated cells exhibit a higher capacity to survive to chemo and radiotherapies and have the ability to incite tumor relapse. Inducing cancer cell differentiation would abolish their self-renewal and invasive capacity and could be combined with the current standard of care, especially in poorly differentiated and aggressive tumors (with worst prognosis). However, differentiation therapy is still in its early stages and the intrinsic complexity of solid tumor heterogeneity demands innovative approaches in order to be efficiently translated into the clinic. We demonstrate here that microRNA 203, a potent driver of differentiation in pluripotent stem cells (ESCs and iPSCs), promotes the differentiation of mammary gland tumor cells. Combining mouse in vivo approaches and both mouse and human-derived tridimensional organoid cultures, we report that miR-203 influences the self-renewal capacity, plasticity and differentiation potential of breast cancer cells and prevents tumor cell growth in vivo. Our work sheds light on differentiation-based antitumor therapies and offers miR-203 as a promising tool for directly confronting the tumor-maintaining and regeneration capability of cancer cells. Breast Cancer Res . 2023 ;25(1):91. 10.1186/s13058-023-01690-9 1465-542X Breast cancer research : BCR 37542268 https://hdl.handle.net/20.500.12105/23121 miR-203 drives breast cancer cell differentiation