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oai:repisalud.isciii.es:20.500.12105/231142024-11-28T15:57:51Zcom_20.500.12105_2173com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19597col_20.500.12105_16938col_20.500.12105_16962col_20.500.12105_16973col_20.500.12105_16987

00925njm 22002777a 4500 dc Hernando, Jorge author Roca-Herrera, Maria author García-Álvarez, Alejandro author Raymond, Eric author Ruszniewski, Philippe author Kulke, Matthew H author Grande, Enrique author García-Carbonero, Rocio author Castellano, Daniel author Salazar, Ramón author Ibrahim, Toni author Teule, Alex author Alonso, Vicente author Fazio, Nicola author Valle, Juan W author Tafuto, Salvatore author Carmona, Ana author Navarro, Victor author Capdevila, Jaume author 2023-07 PURPOSE: There is an increasing interest in the role of sex and gender in cancer patients. The impact of sex differences in oncological systemic therapies is still unknown, and there is a lack of evidence specially in uncommon neoplasms like neuroendocrine tumours (NET). In the present study, we combine the differential toxicities by sex in five published clinical trials with multikinase inhibitors (MKI) in gastroenteropancreatic (GEP) NET. METHODS: We performed a pooled univariate analysis of reported toxicity in patients treated in five phase 2 and phase 3 clinical trials with MKI in the GEP NET setting: sunitinib (SU11248, SUN1111), Pazopanib (PAZONET), sorafenib-bevacizumab (GETNE0801) and Lenvatinib (TALENT). Differential toxicities between male and female patients were evaluated considering relationship with study drug and different weights of each trial by random effect adjustment. RESULTS: We found nine toxicities which were more frequent in female patients (leukopenia, alopecia, vomiting, headache, bleeding, nausea, dysgeusia, neutrophil count decreased and dry mouth) and two toxicities being more frequent in male patients (Anal Symptoms and Insomnia). Asthenia and diarrhoea were the only severe (Grade 3-4) toxicities more frequent in female patients. CONCLUSIONS: Sex-related differences in toxicity with the MKI treatment require targeted information and individualised management of patients with NET. Differential reporting of toxicity should be promoted when clinical trials are published. Eur J Cancer . 2023 :188:39-48 10.1016/j.ejca.2023.04.013 1879-0852 European journal of cancer (Oxford, England : 1990) 37196483 https://hdl.handle.net/20.500.12105/23114 Sex differences on multikinase inhibitors toxicity in patients with advanced gastroenteropancreatic neuroendocrine tumours