2026-05-16T22:10:09Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/230522024-11-29T02:21:24Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967

00925njm 22002777a 4500 dc Fullana Barcelo, Maria Isabel author Asensio Rodriguez, Javier author Artigues Serra, Francisca author Ferré Beltrán, Adrián author Salva D'Agosto, Pilar author Almodovar Garcia, Maria author Lopez Bilbao, Maria del Carmen author Sanchis, Pilar author Reina, Jordi author Riera, Melchor author 2020-10 Background: Information on the characteristics of patients with nosocomial influenza and associated complications is scarce. This study compared epidemiological and clinical characteristics of patients admitted with hospital-acquired influenza (HAI) to those with community-acquired influenza (CAI) and analyzed risk factors associated with complications. Methods: This retrospective, observational study included all adult patients with confirmed influenza virus infection admitted to Son Espases University Hospital during the influenza season in Spain (October to May) from 2012-2013 to 2015-2016. Symptom onset before admission was included as CAI, and 2 days after admission or within 48 hours after previous discharge were considered as HAI. Results: Overall, 666 patients with laboratory-confirmed influenza were included; 590 (88.6%) and 76 (11.4%) had CAI and HAI, respectively. Baseline characteristics and vaccination rates were similar in both groups. Patients with HAI had significantly fewer symptoms, less radiological alterations, and earlier microbiological diagnosis than those with CAI. Eighty-five (14.4%) and 20 (27.6%) CAI and HAI patients, respectively, experienced at least one complication, including septic shock, admission to the intensive care unit, mechanical ventilation or evolution to death (any one, P = .003). Univariate and multivariate binary logistic regression was performed to assess independent risk factors associated with the occurrence of complications: nosocomial infection, diabetes, oseltamivir treatment, having received no vaccination, microbiological delay, dyspnea, and the state of confusion were the most important significant factors. Conclusions: Our study shows the need to implement microbiological diagnostic measures in the first 48 hours to reduce HAI frequency and associated complications. Fullana Barcelo MI, Asensio Rodriguez J, Artigues Serra F, Ferre Beltran A, Salva D'Agosto P, Almodovar Garcia M, et al. Epidemiological and clinical characteristics of community-acquired and nosocomial influenza cases and risk factors associated with complications: A four season analysis of all adult patients admitted in a tertiary hospital. Influenza Other Respir Viruses. Epub 2020 Oct 30. 10.1111/irv.12823 1750-2659 1750-2640 Influenza and Other Respiratory Viruses http://hdl.handle.net/20.500.13003/8987 33125178 L2007113691 2-s2.0-85094629919 https://hdl.handle.net/20.500.12105/23052 585032300001 Community-acquired influenza Complications Epidemiology hospital-acquired influenza Epidemiological and clinical characteristics of community-acquired and nosocomial influenza cases and risk factors associated with complications: A four season analysis of all adult patients admitted in a tertiary hospital