2026-08-29T14:15:09Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/230332024-11-28T22:57:21Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967
Repisalud
author
Adrover-Jaume, Cristina
author
Rojo Molinero, Estrella
author
Clemente, Antonio
author
Russell, Steven M
author
Arranz Izquierdo, Javier
author
Oliver, Antonio
author
de la Rica, Roberto
2024-09-13T09:15:56Z
2024-09-13T09:15:56Z
2020-12-21
Adrover Jaume C, Rojo Molinero E, Clemente A, Russell S, Arranz J, Oliver A, et al. Mobile origami immunosensors for the rapid detection of urinary tract infections. Analyst. 2020 Dec 21;145(24):7916-21.
10.1039/d0an01218a
1364-5528
0003-2654
Analyst
http://hdl.handle.net/20.500.13003/12220
33020772
L633121435
2-s2.0-85099151767
https://hdl.handle.net/20.500.12105/23033
607343400013
Urinary tract infections (UTI) have a high prevalence and can yield poor patient outcomes if they progress to urosepsis. Here we introduce mobile origami biosensors that detect UTIs caused by E. coli at the bedside in less than 7 minutes. The origami biosensors are made of a single piece of paper that contains antibody-decorated nanoparticles. When the urine sample contains E. coli, the biosensors generate colored spots on the paper strip. These are then quantified with a mobile app that calculates the pixel intensity in real time. The tests are highly specific and do not cross-react with other common uropathogens. Furthermore, the biosensors only yielded one false negative result when queried with a panel containing 57 urine samples from patients, which demonstrates that they have excellent sensitivity and specificity. This, along with the rapid assay time and smartphone-based detection, makes them useful for aiding in the diagnosis of UTIs at the point of care.
eng
Mobile origami immunosensors for the rapid detection of urinary tract infections
research article