2026-05-22T00:02:32Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/230332024-11-28T22:57:21Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967

00925njm 22002777a 4500 dc Adrover-Jaume, Cristina author Rojo Molinero, Estrella author Clemente, Antonio author Russell, Steven M author Arranz Izquierdo, Javier author Oliver, Antonio author de la Rica, Roberto author 2020-12-21 Urinary tract infections (UTI) have a high prevalence and can yield poor patient outcomes if they progress to urosepsis. Here we introduce mobile origami biosensors that detect UTIs caused by E. coli at the bedside in less than 7 minutes. The origami biosensors are made of a single piece of paper that contains antibody-decorated nanoparticles. When the urine sample contains E. coli, the biosensors generate colored spots on the paper strip. These are then quantified with a mobile app that calculates the pixel intensity in real time. The tests are highly specific and do not cross-react with other common uropathogens. Furthermore, the biosensors only yielded one false negative result when queried with a panel containing 57 urine samples from patients, which demonstrates that they have excellent sensitivity and specificity. This, along with the rapid assay time and smartphone-based detection, makes them useful for aiding in the diagnosis of UTIs at the point of care. Adrover Jaume C, Rojo Molinero E, Clemente A, Russell S, Arranz J, Oliver A, et al. Mobile origami immunosensors for the rapid detection of urinary tract infections. Analyst. 2020 Dec 21;145(24):7916-21. 10.1039/d0an01218a 1364-5528 0003-2654 Analyst http://hdl.handle.net/20.500.13003/12220 33020772 L633121435 2-s2.0-85099151767 https://hdl.handle.net/20.500.12105/23033 607343400013 Mobile origami immunosensors for the rapid detection of urinary tract infections