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oai:repisalud.isciii.es:20.500.12105/230072024-11-28T18:04:16Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16961col_20.500.12105_16967col_20.500.12105_16983

00925njm 22002777a 4500 dc Castro-Barquero, Sara author Ribo-Coll, Margarita author Lassale, Camille author Tresserra-Rimbau, Anna author Castaner, Olga author Pinto, Xavier author Martinez-Gonzalez, Miguel Angel author Sorli, Jose, V author Salas-Salvado, Jordi author Lapetra, Jose author Gomez-Gracia, Enrique author Alonso-Gomez, Angel M author Fiol Sala, Miquel author Serra-Majem, Lluis author Sacanella, Emilio author Javier Basterra-Gortari, Francisco author Portoles, Olga author Babio, Nancy author Cofan, Montserrat author Ros, Emilio author Estruch, Ramon author Hernaez, Alvaro author 2020-12 Our aim is to assess whether following a Mediterranean Diet (MedDiet) decreases the risk of initiating antithrombotic therapies and the cardiovascular risk associated with its use in older individuals at high cardiovascular risk. We evaluate whether participants of the PREvencion con DIeta MEDiterranea (PREDIMED) study allocated to a MedDiet enriched in extra-virgin olive oil or nuts (versus a low-fat control intervention) disclose differences in the risk of initiation of: (1) vitamin K epoxide reductase inhibitors (acenocumarol/warfarin; n = 6772); (2) acetylsalicylic acid as antiplatelet agent (n = 5662); and (3) other antiplatelet drugs (cilostazol/clopidogrel/dipyridamole/ditazol/ticlopidine/triflusal; n = 6768). We also assess whether MedDiet modifies the association between the antithrombotic drug baseline use and incident cardiovascular events. The MedDiet intervention enriched with extra-virgin olive oil decreased the risk of initiating the use of vitamin K epoxide reductase inhibitors relative to control diet (HR: 0.68 [0.46-0.998]). Their use was also more strongly associated with an increased risk of cardiovascular disease in participants not allocated to MedDiet interventions (HRcontrol diet: 4.22 [1.92-9.30], HRMedDiets: 1.71 [0.83-3.52], p-interaction = 0.052). In conclusion, in an older population at high cardiovascular risk, following a MedDiet decreases the initiation of antithrombotic therapies and the risk of suffering major cardiovascular events among users of vitamin K epoxide reductase inhibitors. Castro-Barquero S, Ribo-Coll M, Lassale C, Tresserra-Rimbau A, Castaner O, Pinto X, et al. Mediterranean Diet Decreases the Initiation of Use of Vitamin K Epoxide Reductase Inhibitors and Their Associated Cardiovascular Risk: A Randomized Controlled Trial. Nutrients. 2020 Dec;12(12):3895. 10.3390/nu12123895 2072-6643 Nutrients http://hdl.handle.net/20.500.13003/14219 33352771 L2005673306 2-s2.0-85098259145 https://hdl.handle.net/20.500.12105/23007 602367100001 Mediterranean Diet Randomized controlled trials Prevention 4-hydroxycoumarins Platelet aggregation inhibitors Mediterranean Diet Decreases the Initiation of Use of Vitamin K Epoxide Reductase Inhibitors and Their Associated Cardiovascular Risk: A Randomized Controlled Trial