2026-07-21T14:20:13Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/230022024-11-29T01:52:21Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967
Repisalud
author
Box, Antonio
author
Capó Fiol, Xavier
author
Tejada Gavela, Silvia
author
Catanese, Gaetano
author
Grau, Amalia
author
Deudero, Salud
author
Soldevila Verdeguer, Carla
author
Valencia, Jose Maria
2024-09-13T09:15:47Z
2024-09-13T09:15:47Z
2020-11
Box A, Capo X, Tejada S, Catanese G, Grau A, Deudero S, et al. Reduced Antioxidant Response of the Fan Mussel Pinna nobilis Related to the Presence of Haplosporidium pinnae. Pathogens. 2020 Nov;9(11):932.
10.3390/pathogens9110932
2076-0817
Pathogens
http://hdl.handle.net/20.500.13003/17604
33187065
L2005439214
2-s2.0-85096020428
https://hdl.handle.net/20.500.12105/23002
593739600001
The endemic fan mussel (Pinna nobilis) in the Mediterranean Sea is at high risk of disappearance due to massive mortality events. The aim of the study was to evaluate the antioxidant response of P. nobilis collected in the Balearic Islands (Western Mediterranean) before and after the mass mortality event. Individuals collected before (between 2011 and 2012) and after (between 2016 and 2017) the event were analyzed by histological, molecular, and biochemical methods to compare pathogenic loads and biochemical responses. All the individuals collected during 2016-2017 presented symptoms of the disease and were positive for Haplosporidium pinnae, while acid-fast bacteria or/and Gram-negative bacteria were detected in some individuals of both sampling periods. The activities of the antioxidant enzymes catalase and superoxide dismutase in the gills were significantly lower in P. nobilis affected with the parasite compared to those in the asymptomatic ones, while levels of malondialdehyde, as an indicator of lipid peroxidation, were higher in infected individuals. When analyzing the differential effects of H. pinnae and Mycobacterium sp. on P. nobilis, it was observed that significant effects on biomarkers were only observed in the presence of H. pinnae. Co-infection of P. nobilis by H. pinnae with other pathogens such as Mycobacterium sp. constitutes a serious problem due to its high mortality rate in the Balearic Island waters. This concerning situation for P. nobilis is favored by a reduction in antioxidant defenses related to H. pinnae infection that induces oxidative stress and cell damage.
eng
Pinna nobilis
Fan mussel
Antioxidant defenses
Oxidative stress
Haplosporidium pinnae
Protozoan parasite
Balearic Islands
Reduced Antioxidant Response of the Fan Mussel Pinna nobilis Related to the Presence of Haplosporidium pinnae
research article