2026-07-22T20:10:51Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/229982024-11-28T22:39:25Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967col_20.500.12105_16968
Repisalud
author
Galarregui, Cristina
author
Marin-Alejandre, Bertha Araceli
author
Perez-Diaz-Del-Campo, Nuria
author
Cantero, Irene
author
Monreal, J. Ignacio
author
Elorz, Mariana
author
Benito-Boillos, Alberto
author
Herrero, Jose Ignacio
author
Tur, Josep A
author
Martinez, J. Alfredo
author
Zulet, M. Angeles
author
Abete, Itziar
2024-09-13T09:15:46Z
2024-09-13T09:15:46Z
2020-11
Galarregui C, Marin-Alejandre BA, Perez-Diaz-del-Campo N, Cantero I, Monreal JI, Elorz M, et al. Predictive Value of Serum Ferritin in Combination with Alanine Aminotransferase and Glucose Levels for Noninvasive Assessment of NAFLD: Fatty Liver in Obesity (FLiO) Study. Diagnostics. 2020 Nov;10(11):917.
10.3390/diagnostics10110917
2075-4418
Diagnostics
http://hdl.handle.net/20.500.13003/17626
33171699
L2010972926
2-s2.0-85100710705
https://hdl.handle.net/20.500.12105/22998
592801700001
The identification of affordable noninvasive biomarkers for the diagnosis and characterization of nonalcoholic fatty liver disease (NAFLD) is a major challenge for the research community. This study aimed to explore the usefulness of ferritin as a proxy biomarker of NAFLD condition, alone or in combination with other routine biochemical parameters. Subjects with overweight/obesity and ultrasound-confirmed liver steatosis (n = 112) from the Fatty Liver in Obesity (FLiO) study were assessed. The hepatic evaluation considered magnetic resonance imaging, ultrasonography, and credited routine blood liver biomarkers. Anthropometry and body composition, dietary intake (by means of a validated 137-item food frequency questionnaire), and specific biochemical markers were also determined. Serum ferritin levels were analyzed using a chemiluminescent microparticle immunoassay kit. Lower serum ferritin concentrations were associated with general better liver health and nutritional status. The evaluation of ferritin as a surrogate of liver damage by means of quantile regression analyses showed a positive association with alanine aminotransferase (ALT) (beta = 19.21; p <= 0.001), liver fat content (beta = 8.70; p = 0.008), and hepatic iron (beta = 3.76; p <= 0.001), after adjusting for potential confounders. In receiver operating characteristic (ROC) analyses, the panel combination of blood ferritin, glucose, and ALT showed the best prediction for liver fat mass (area under the curve (AUC) 0.82). A combination of ferritin and ALT showed the higher predictive ability for estimating liver iron content (AUC 0.73). This investigation demonstrated the association of serum ferritin with liver health as well as with glucose and lipid metabolism markers in subjects with NAFLD. Current findings led to the identification of ferritin as a potential noninvasive predictive biomarker of NAFLD, whose surrogate value increased when combined with other routine biochemical measurements (glucose/ALT).
eng
Fatty liver
Insulin resistance
Iron
Obesity
Biomarker
Metabolism
Predictive Value of Serum Ferritin in Combination with Alanine Aminotransferase and Glucose Levels for Noninvasive Assessment of NAFLD: Fatty Liver in Obesity (FLiO) Study
research article