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oai:repisalud.isciii.es:20.500.12105/229892024-11-28T20:53:49Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967

00925njm 22002777a 4500 dc Mercader-Barceló, Josep author Truyols-Vives, Joan author Rio-Bocos, Carlos author Lopez-Safont, Nora author Sala Llinàs, Ernest author Chaplin, Alice author 2020-09 Idiopathic pulmonary fibrosis (IPF) is a chronic disease mainly associated with aging and, to date, its causes are still largely unknown. It has been shown that dietary habits can accelerate or delay the occurrence of aging-related diseases; however, their potential role in IPF development has been underestimated so far. The present review summarizes the evidence regarding the relationship between diet and IPF in humans, and in animal models of pulmonary fibrosis, in which we discuss the bioactivity of specific dietary food ingredients, including fatty acids, peptides, amino acids, carbohydrates, vitamins, minerals and phytochemicals. Interestingly, many animal studies reveal preventive and therapeutic effects of particular compounds. Furthermore, it has been recently suggested that the lung and gut microbiota could be involved in IPF, a relationship which may be linked to changes in immunological and inflammatory factors. Thus, all the evidence so far puts forward the idea that the gut-lung axis could be modulated by dietary factors, which in turn have an influence on IPF development. Overall, the data reviewed here support the notion of identifying food ingredients with potential benefits in IPF, with the ultimate aim of designing nutritional approaches as an adjuvant therapeutic strategy. Mercader-Barcelo J, Truyols-Vives J, Rio C, Lopez-Safont N, Sala-Llinas E, Chaplin A. Insights into the Role of Bioactive Food Ingredients and the Microbiome in Idiopathic Pulmonary Fibrosis. Int J Mol Sci. 2020 Sep;21(17):6051. http://hdl.handle.net/20.500.13003/9598 https://hdl.handle.net/20.500.12105/22989 32842664 10.3390/ijms21176051 1422-0067 International Journal of Molecular Sciences 2-s2.0-85089922841 569943300001 L2004956974 Idiopathic pulmonary fibrosis Diet Microbiota Gut-lung axis Insights into the Role of Bioactive Food Ingredients and the Microbiome in Idiopathic Pulmonary Fibrosis