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oai:repisalud.isciii.es:20.500.12105/229832024-11-29T06:58:06Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967

00925njm 22002777a 4500 dc Pomar, Catalina Amadora author Sanchez, Juana author Palou, Andreu author 2020-08 We aimed to analyse the effects of maternal intake of an unbalanced diet during lactation in the composition and the levels of proteins present in milk. Milk samples from control nursing dams (C-dams) or from nursing dams fed a cafeteria diet during lactation (CAF-dams) were obtained. We conducted a proteomic approach to identify significantly altered proteins in breast milk of C- and CAF-dams, and evaluated the levels of leptin, adiponectin and irisin for their implication in energy homeostasis. One-dimensional SDS-polyacrylamide gel electrophoresis (SDS-PAGE), followed by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS), revealed that the bands that presented a lower intensity in CAF-dams than control contain some caseins (alpha-S1-casein, alpha-S2-casein like B, and beta-casein), alpha-lactalbumin and haptoglobin. Leptin and adiponectin levels were greater in the breast milk of CAF-dams than in controls, while levels of irisin were lower. In summary, the relative concentration of bioactive peptides was influenced by maternal diet consumption during lactation; these changes at early stages of life could influence the phenotypic traits of the offspring. Pomar CA, Sanchez J, Palou A. The Intake of a Cafeteria Diet in Nursing Rats Alters the Breast Milk Concentration of Proteins Important for the Development of Offspring. Nutrients. 2020 Aug;12(8):2470. 10.3390/nu12082470 2072-6643 Nutrients http://hdl.handle.net/20.500.13003/9853 32824434 L2004921655 2-s2.0-85089704465 https://hdl.handle.net/20.500.12105/22983 577861900001 Milk composition Bioactive proteins Lactation The Intake of a Cafeteria Diet in Nursing Rats Alters the Breast Milk Concentration of Proteins Important for the Development of Offspring